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SUMO1

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq]
Full Name
SUMO1
Function
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394).
Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376).
Biological Process
Biological Process cellular response to cadmium ionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to heatManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process DNA repairManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of action potentialManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of delayed rectifier potassium channel activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of DNA bindingManual Assertion Based On ExperimentIDA:CAFA
Biological Process negative regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIDA:GO_Central
Biological Process negative regulation of protein import into nucleusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of transcription by transcription factor localizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process PML body organizationIEA:Ensembl
Biological Process positive regulation of ATPase-coupled calcium transmembrane transporter activityIEA:Ensembl
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein-containing complex assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process protein localization to nuclear poreIEA:Ensembl
Biological Process protein stabilizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein sumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of cardiac muscle cell contractionIEA:Ensembl
Biological Process regulation of protein localizationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process roof of mouth developmentISS:UniProtKB
Cellular Location
Nucleus membrane
Nucleus speckle
Cytoplasm
Nucleus, PML body
Cell membrane
Nucleus
Recruited by BCL11A into the nuclear body (By similarity).
In the presence of ZFHX3, sequesterd to nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body (PubMed:24651376).
Involvement in disease
Non-syndromic orofacial cleft 10 (OFC10):
A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.
PTM
Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
Polymeric SUMO1 chains undergo polyubiquitination by RNF4.

Anti-SUMO1 antibodies

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Target: SUMO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: S1MT-2
Application*: F, IF, P, WB
Target: SUMO1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1955
Application*: WB
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Chicken, Mouse, Rat, Frog, Zebrafish
Clone: 21C7
Application*: IF, IP, WB
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: SM1/495
Application*: WB, F, E, IF, IP, P, C, MC
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SPM571
Application*: WB, F, E, IF, IP, P, C, MC
Target: SUMO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-5575
Application*: IF
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Chicken, Mouse, Frog
Application*: IP, WB
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBFYA-0224
Application*: IA, P, WB
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1710
Application*: WB, IP
Target: SUMO1
Host: Mouse
Specificity: Human
Clone: CBXS-0860
Application*: IF, IH, IP, WB
Target: SUMO1
Host: Rabbit
Specificity: Human
Clone: CBXS-0859
Application*: CI, F, IF, IH, IP, WB
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0858
Application*: C, P
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-0857
Application*: E, IF, WB
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBXF-2273
Application*: IF, WB
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-4851
Application*: E, WB
Target: SUMO1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse, Rat, Human, Monkey
Clone: CBXS-5012
Application*: WB, C, IF
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5141
Application*: IC, WB
Target: SUMO1
Host: Rabbit
Specificity: Human, Mouse, Rat
Clone: CBXS-0853
Application*: WB, IH, IF, IP
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 6A92
Application*: E, IF, WB
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: 1SUM-1C6
Application*: E, WB
Target: SUMO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-096
Application*: E, IH, F, IP
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: PT006
Application*: WB, Dot, E
Target: SUMO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: C21A7
Application*: WB, IP, IF (IC)
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5785
Application*: E, WB
Target: SUMO1
Host: Rabbit
Specificity: Human, Mouse, Rat, Monkey
Clone: CBXS-6008
Application*: WB, IP, P
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBXS-3862
Application*: IA, P, W
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: CBXS-4339
Application*: WB
Target: SUMO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXS-5553
Application*: P, IP, WB
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 66AT1273.94
Application*: WB
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-0852
Application*: P, IF, SE, E, WB
Target: SUMO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXS-0854
Application*: WB, P, IF, IP, F, CI
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 6C9-E9-D7
Application*: P, F, WB, IF
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3D7
Application*: WB, E
Target: SUMO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: C9H1
Application*: WB, IP, P
Target: SUMO1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBHb341
Application*: Immuno assays, IHC-P, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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