TACR2

This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]

Full Name

Tachykinin Receptor 2

Function

This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K> neuromedin-K> substance P.

Biological Process

Biological Process intestine smooth muscle contractionIEA:Ensembl
Biological Process muscle contractionTAS:ProtInc1 Publication
Biological Process negative regulation of luteinizing hormone secretionIEA:Ensembl
Biological Process operant conditioningIEA:Ensembl
Biological Process positive regulation of acetylcholine secretion, neurotransmissionIEA:Ensembl
Biological Process positive regulation of flagellated sperm motilityIMP:UniProtKB1 Publication
Biological Process positive regulation of smooth muscle contractionTAS:ProtInc1 Publication
Biological Process positive regulation of uterine smooth muscle contractionIEA:Ensembl
Biological Process positive regulation of vascular permeabilityIEA:Ensembl
Biological Process prolactin secretionIEA:Ensembl
Biological Process response to electrical stimulusIEA:Ensembl
Biological Process tachykinin receptor signaling pathwayTAS:ProtInc1 Publication

Cellular Location

Cell membrane

Topology

Extracellular: 1-32
Helical: 33-56
Cytoplasmic: 57-69
Helical: 70-90
Extracellular: 91-107
Helical: 108-129
Cytoplasmic: 130-149
Helical: 150-170
Extracellular: 171-196
Helical: 197-218
Cytoplasmic: 219-251
Helical: 252-272
Extracellular: 273-290
Helical: 291-310
Cytoplasmic: 311-398