TM4SF4

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq]

transmembrane 4 L six family member 4

Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.

Tissue regeneration

Membrane

Cytoplasmic: 1-9
Helical: 10-30
Extracellular: 31-49
Helical: 50-70
Cytoplasmic: 71-93
Helical: 94-114
Extracellular: 115-158
Helical: 159-179
Cytoplasmic: 180-202

N-glycosylated. Glycosylation is required for the growth inhibitory effect.