TOE1

TOE1 (Target Of EGR1, Exonuclease) is a Protein Coding gene. Diseases associated with TOE1 include Pontocerebellar Hypoplasia, Type 7 and Pontocerebellar Hypoplasia. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

Full Name

TOE1 Gene(Protein Coding) Target Of EGR1, Exonuclease

Function

Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684).

Biological Process

Biological Process RNA phosphodiester bond hydrolysis, exonucleolytic Source:HGNC1 Publication
Biological Process snRNA 3'-end processing Source:UniProtKB1 Publication

Cellular Location

Nucleus, nucleolus
Nucleus speckle
Localizes to nuclear speckles.

Involvement in disease

Pontocerebellar hypoplasia 7 (PCH7):
A form of pontocerebellar hypoplasia, a group of related disorders characterized by underdevelopment of the pons and the cerebellum. Pontocerebellar hypoplasia also causes impaired growth of other parts of the brain, leading to an unusually small head size. PCH7 patients manifest delayed psychomotor development, hypotonia, breathing abnormalities, and gonadal abnormalities.

Anti-TOE1 antibodies

Mouse Anti-TOE1 Recombinant Antibody (2D7) (CBMAB-A9419-LY)

Datasheet

SDS

Target: TOE1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2D7

Application*: WB, E

Mouse Anti-TOE1 Recombinant Antibody (1D8) (CBMAB-A9418-LY)

Datasheet

SDS

Target: TOE1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1D8

Application*: WB, E

Mouse Anti-TOE1 Recombinant Antibody (1C12) (CBMAB-A9417-LY)

Datasheet

SDS

Target: TOE1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1C12

Application*: WB, E

Mouse Anti-TOE1 Recombinant Antibody (2E4) (CBMAB-A9416-LY)

Datasheet

SDS

Target: TOE1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2E4

Application*: WB, E

Mouse Anti-TOE1 Recombinant Antibody (CBYJT-4147) (CBMAB-T3596-YJ)

Datasheet

SDS

Target: TOE1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-4147

Application*: F, IC, IP, WB

Mouse Anti-TOE1 Recombinant Antibody (3154C2a) (CBMAB-T3595-YJ)

Datasheet

SDS

Target: TOE1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3154C2a

Application*: DB, IC, IP, WB, F

Mouse Anti-TOE1 Recombinant Antibody (CBYJT-4146) (CBMAB-T3594-YJ)

Datasheet

SDS

Target: TOE1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-4146

Application*: E, WB

Mouse Anti-TOE1 Recombinant Antibody (CBYJT-4145) (CBMAB-T3593-YJ)

Datasheet

SDS

Target: TOE1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-4145

Application*: E, WB

Mouse Anti-TOE1 Recombinant Antibody (CBYJT-4144) (CBMAB-T3592-YJ)

Datasheet

SDS

Target: TOE1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-4144

Application*: E, P, WB

Mouse Anti-TOE1 Recombinant Antibody (CBYJT-4143) (CBMAB-T3591-YJ)

Datasheet

SDS

Target: TOE1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-4143

Application*: E, IF, WB

Mouse Anti-TOE1 Recombinant Antibody (CBYJT-4142) (CBMAB-T3590-YJ)

Datasheet

SDS

Target: TOE1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-4142

Application*: E, IF, P, WB

TOE1 Matched Antibody Pair (1250) (APMAB-1250LY)

Datasheet

SDS

Target: TOE1

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)