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TOE1

TOE1 (Target Of EGR1, Exonuclease) is a Protein Coding gene. Diseases associated with TOE1 include Pontocerebellar Hypoplasia, Type 7 and Pontocerebellar Hypoplasia. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.
Full Name
TOE1 Gene(Protein Coding) Target Of EGR1, Exonuclease
Function
Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684).
Biological Process
Biological Process RNA phosphodiester bond hydrolysis, exonucleolytic Source:HGNC1 Publication
Biological Process snRNA 3'-end processing Source:UniProtKB1 Publication
Cellular Location
Nucleus, nucleolus
Nucleus speckle
Localizes to nuclear speckles.
Involvement in disease
Pontocerebellar hypoplasia 7 (PCH7):
A form of pontocerebellar hypoplasia, a group of related disorders characterized by underdevelopment of the pons and the cerebellum. Pontocerebellar hypoplasia also causes impaired growth of other parts of the brain, leading to an unusually small head size. PCH7 patients manifest delayed psychomotor development, hypotonia, breathing abnormalities, and gonadal abnormalities.
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Anti-TOE1 antibodies

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Mouse Anti-TOE1 Recombinant Antibody (2D7) (CBMAB-A9419-LY)

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Target: TOE1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2D7
Application*: WB, E
Datasheet SDS

Mouse Anti-TOE1 Recombinant Antibody (1D8) (CBMAB-A9418-LY)

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Target: TOE1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D8
Application*: WB, E
Datasheet SDS

Mouse Anti-TOE1 Recombinant Antibody (1C12) (CBMAB-A9417-LY)

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Target: TOE1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C12
Application*: WB, E
Datasheet SDS

Mouse Anti-TOE1 Recombinant Antibody (2E4) (CBMAB-A9416-LY)

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Target: TOE1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2E4
Application*: WB, E
Datasheet SDS

Mouse Anti-TOE1 Recombinant Antibody (CBYJT-4147) (CBMAB-T3596-YJ)

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Target: TOE1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4147
Application*: F, IC, IP, WB
Datasheet SDS

Mouse Anti-TOE1 Recombinant Antibody (3154C2a) (CBMAB-T3595-YJ)

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Target: TOE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3154C2a
Application*: DB, IC, IP, WB, F
Datasheet SDS

Mouse Anti-TOE1 Recombinant Antibody (CBYJT-4146) (CBMAB-T3594-YJ)

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Target: TOE1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4146
Application*: E, WB
Datasheet SDS

Mouse Anti-TOE1 Recombinant Antibody (CBYJT-4145) (CBMAB-T3593-YJ)

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Target: TOE1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4145
Application*: E, WB
Datasheet SDS

Mouse Anti-TOE1 Recombinant Antibody (CBYJT-4144) (CBMAB-T3592-YJ)

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Target: TOE1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4144
Application*: E, P, WB
Datasheet SDS

Mouse Anti-TOE1 Recombinant Antibody (CBYJT-4143) (CBMAB-T3591-YJ)

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Target: TOE1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4143
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-TOE1 Recombinant Antibody (CBYJT-4142) (CBMAB-T3590-YJ)

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Target: TOE1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4142
Application*: E, IF, P, WB
Datasheet SDS

TOE1 Matched Antibody Pair (1250) (APMAB-1250LY)

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Target: TOE1
Specificity: Human
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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