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Mouse Anti-TOE1 Recombinant Antibody (3154C2a) (CBMAB-T3595-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TOE1 (Target Of EGR1, Exonuclease). The antibody can be used for immunoassay techniques, such as Dot, ICC, IP, WB, FC.
See all TOE1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3154C2a
Antibody Isotype
IgG1
Application
Dot, ICC, IP, WB, FC

Basic Information

Immunogen
TOE1 antibody was raised in mouse using recombinant Human Target Of Egr1, Member 1 (Nuclear) (Toe1)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.05% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TOE1 Gene(Protein Coding) Target Of EGR1, Exonuclease
Introduction
TOE1 (Target Of EGR1, Exonuclease) is a Protein Coding gene. Diseases related to TOE1 include Pontocerebellar Hypoplasia, Type 7 and Pontocerebellar Hypoplasia. Gene Ontology (GO) annotations related to TOE1 include nucleic acid binding.
Entrez Gene ID
114034
UniProt ID
Q96GM8
Alternative Names
Target Of EGR1, Exonuclease; Target Of EGR1, Member 1 (Nuclear); Target Of EGR1 Protein 1; HCaf1z; PCH7
Function
Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684).
Biological Process
Biological Process RNA phosphodiester bond hydrolysis, exonucleolytic Source:HGNC1 Publication
Biological Process snRNA 3'-end processing Source:UniProtKB1 Publication
Cellular Location
Nucleus, nucleolus
Nucleus speckle
Localizes to nuclear speckles.
Involvement in disease
Pontocerebellar hypoplasia 7 (PCH7):
A form of pontocerebellar hypoplasia, a group of related disorders characterized by underdevelopment of the pons and the cerebellum. Pontocerebellar hypoplasia also causes impaired growth of other parts of the brain, leading to an unusually small head size. PCH7 patients manifest delayed psychomotor development, hypotonia, breathing abnormalities, and gonadal abnormalities.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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