Mouse Anti-TOE1 Recombinant Antibody (1D8) (CBMAB-A9418-LY)

Name: Mouse Anti-TOE1 Recombinant Antibody (1D8)
SKU: CBMAB-A9418-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1D8

Application

WB, ELISA

Immunogen

TOE1 (AAH09364, 1 a.a. ~ 510 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

TOE1 Gene(Protein Coding) Target Of EGR1, Exonuclease

Entrez Gene ID

114034

UniProt ID

Q96GM8

Alternative Names

FLJ13949

Function

Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684).

Biological Process

Biological Process RNA phosphodiester bond hydrolysis, exonucleolytic Source:HGNC1 Publication
Biological Process snRNA 3'-end processing Source:UniProtKB1 Publication

Cellular Location

Nucleus, nucleolus
Nucleus speckle
Localizes to nuclear speckles.

Involvement in disease

Pontocerebellar hypoplasia 7 (PCH7):
A form of pontocerebellar hypoplasia, a group of related disorders characterized by underdevelopment of the pons and the cerebellum. Pontocerebellar hypoplasia also causes impaired growth of other parts of the brain, leading to an unusually small head size. PCH7 patients manifest delayed psychomotor development, hypotonia, breathing abnormalities, and gonadal abnormalities.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

TOE1 Matched Antibody Pair (1250) (CAT#: APMAB-1250LY)

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TOE1 Matched Antibody Pair (1250) (CAT#: APMAB-1250LY)

Mouse Anti-TOE1 Recombinant Antibody (2E4) (CAT#: CBMAB-A9416-LY)

Mouse Anti-TOE1 Recombinant Antibody (2D7) (CAT#: CBMAB-A9419-LY)

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Mouse Anti-TOE1 Recombinant Antibody (CBYJT-4146) (CAT#: CBMAB-T3594-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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