TPTE2

TPTE2 is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.

Full Name

Transmembrane Phosphoinositide 3-Phosphatase And Tensin Homolog 2

Function

Acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate.
Isoform 4
Shows no phosphoinositide phosphatase activity.

Biological Process

Biological Process cell motility Source:GO_Central1 Publication
Biological Process dephosphorylation Source:GO_Central1 Publication
Biological Process negative regulation of cell population proliferation Source:GO_Central1 Publication
Biological Process phosphatidylinositol 3-kinase signaling Source:GO_Central1 Publication
Biological Process phosphatidylinositol biosynthetic process Source:Reactome
Biological Process phosphatidylinositol dephosphorylation Source:GO_Central1 Publication
Biological Process protein dephosphorylation Source:GO_Central1 Publication
Biological Process regulation of protein kinase B signaling Source:GO_Central1 Publication

Cellular Location

Isoform 3
Endoplasmic reticulum membrane
Isoform 1
Endoplasmic reticulum membrane
Golgi apparatus membrane
Isoform 4
Cytoplasm