TRIP6

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

TRIP6 Thyroid Hormone Receptor Interactor 6

Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.

Biological Process chordate embryonic development Source:Ensembl
Biological Process focal adhesion assembly Source:UniProtKB1 Publication
Biological Process positive regulation of cell migration Source:UniProtKB1 Publication
Biological Process positive regulation of NIK/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process signal transduction Source:GO_Central1 Publication

Cytoplasm, cytoskeleton
Cell junction, focal adhesion
Nucleus
Cytoplasm
Shuttles between nucleus and cytoplasm (PubMed:16624523).
Colocalizes with actin (PubMed:10826496).

Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13.