TRIP6

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Full Name
TRIP6 Thyroid Hormone Receptor Interactor 6
Function
Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.
Biological Process
Biological Process chordate embryonic development Source:Ensembl
Biological Process focal adhesion assembly Source:UniProtKB1 Publication
Biological Process positive regulation of cell migration Source:UniProtKB1 Publication
Biological Process positive regulation of NIK/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process signal transduction Source:GO_Central1 Publication
Cellular Location
Cytoplasm, cytoskeleton
Cell junction, focal adhesion
Nucleus
Cytoplasm
Shuttles between nucleus and cytoplasm (PubMed:16624523).
Colocalizes with actin (PubMed:10826496).
PTM
Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13.
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Anti-TRIP6 antibodies

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Mouse Anti-TRIP6 Recombinant Antibody (CF455) (CBMAB-FT082LY)

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Target: TRIP6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CF455
Application*: ELISA, WB, IHC, FC
Datasheet SDS

Mouse Anti-TRIP6 Recombinant Antibody (3D12) (CBMAB-A9542-LY)

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Target: TRIP6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3D12
Application*: WB, E
Datasheet SDS

Mouse Anti-TRIP6 Recombinant Antibody (CBYJT-4862) (CBMAB-T4408-YJ)

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Target: TRIP6
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBYJT-4862
Application*: SE, E, WB, IF
Datasheet SDS

Mouse Anti-TRIP6 Recombinant Antibody (CBYJT-4861) (CBMAB-T4407-YJ)

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Target: TRIP6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4861
Application*: E, WB, P, IF, IC, F
Datasheet SDS

Mouse Anti-TRIP6 Recombinant Antibody (CBYJT-4860) (CBMAB-T4406-YJ)

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Target: TRIP6
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBYJT-4860
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-TRIP6 Recombinant Antibody (CBYJT-4859) (CBMAB-T4405-YJ)

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Target: TRIP6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4859
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-TRIP6 Recombinant Antibody (CBYJT-4858) (CBMAB-T4404-YJ)

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Target: TRIP6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4858
Application*: E, F, WB
Datasheet SDS

Mouse Anti-TRIP6 Recombinant Antibody (CBWJZ-285) (CBMAB-Z0727-WJ)

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Target: TRIP6
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBWJZ-285
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-TRIP6 Recombinant Antibody (CBWJZ-286) (CBMAB-Z0726-WJ)

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Target: TRIP6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJZ-286
Application*: E, F, WB
Datasheet SDS

Mouse Anti-TRIP6 Recombinant Antibody (CBWJZ-284) (CBMAB-Z0725-WJ)

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Target: TRIP6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human, Rat
Clone: CBWJZ-284
Application*: WB
Datasheet SDS

Mouse Anti-TRIP6 Recombinant Antibody (CBT3776) (V2LY-0625-LY2804)

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Target: TRIP6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3776
Application*: WB, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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