TRIP6
This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Full Name
TRIP6 Thyroid Hormone Receptor Interactor 6
Function
Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.
Biological Process
Biological Process chordate embryonic development Source:Ensembl
Biological Process focal adhesion assembly Source:UniProtKB1 Publication
Biological Process positive regulation of cell migration Source:UniProtKB1 Publication
Biological Process positive regulation of NIK/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process signal transduction Source:GO_Central1 Publication
Biological Process focal adhesion assembly Source:UniProtKB1 Publication
Biological Process positive regulation of cell migration Source:UniProtKB1 Publication
Biological Process positive regulation of NIK/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process signal transduction Source:GO_Central1 Publication
Cellular Location
Cytoplasm, cytoskeleton
Cell junction, focal adhesion
Nucleus
Cytoplasm
Shuttles between nucleus and cytoplasm (PubMed:16624523).
Colocalizes with actin (PubMed:10826496).
Cell junction, focal adhesion
Nucleus
Cytoplasm
Shuttles between nucleus and cytoplasm (PubMed:16624523).
Colocalizes with actin (PubMed:10826496).
PTM
Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13.
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Anti-TRIP6 antibodies
+ Filters
Target: TRIP6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CF455
Application*: ELISA, WB, IHC, FC
Target: TRIP6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3D12
Application*: WB, E
Target: TRIP6
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBYJT-4862
Application*: SE, E, WB, IF
Target: TRIP6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4861
Application*: E, WB, P, IF, IC, F
Target: TRIP6
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBYJT-4860
Application*: E, IF, WB
Target: TRIP6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4859
Application*: E, IF, IP, WB
Target: TRIP6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4858
Application*: E, F, WB
Target: TRIP6
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBWJZ-285
Application*: E, IF, WB
Target: TRIP6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJZ-286
Application*: E, F, WB
Target: TRIP6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human, Rat
Clone: CBWJZ-284
Application*: WB
Target: TRIP6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3776
Application*: WB, F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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