Mouse Anti-TRIP6 Recombinant Antibody (CBWJZ-284) (CBMAB-Z0725-WJ)

Name: Mouse Anti-TRIP6 Recombinant Antibody (CBWJZ-284)
SKU: CBMAB-Z0725-WJ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBWJZ-284

Application

Specificity

Mouse, Human, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

0.25 mg/mL

More Infomation

Target

Full Name

TRIP6 Thyroid Hormone Receptor Interactor 6

Introduction

TRIP6 (Thyroid Hormone Receptor Interactor 6) is a Protein Coding gene. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Among its related pathways are Toll-like receptor signaling pathway and LPA receptor mediated events. Gene Ontology (GO) annotations related to this gene include thyroid hormone receptor binding. An important paralog of this gene is LPP.

Entrez Gene ID

Human	7205
Mouse	22051
Rat	686323

UniProt ID

Human	Q15654
Mouse	Q9Z1Y4
Rat	M0R678

Alternative Names

OIP1; OIP-1; ZRP-1; TRIP-6; TRIP6i2

Function

Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.

Biological Process

Biological Process chordate embryonic development Source:Ensembl
Biological Process focal adhesion assembly Source:UniProtKB1 Publication
Biological Process positive regulation of cell migration Source:UniProtKB1 Publication
Biological Process positive regulation of NIK/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process signal transduction Source:GO_Central1 Publication

Cellular Location

Cytoplasm, cytoskeleton
Cell junction, focal adhesion
Nucleus
Cytoplasm
Shuttles between nucleus and cytoplasm (PubMed:16624523).
Colocalizes with actin (PubMed:10826496).

PTM

Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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