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Mouse Anti-TRIP6 Recombinant Antibody (CBWJZ-286) (CBMAB-Z0726-WJ)

This product is a mouse antibody that recognizes TRIP6. The antibody CBWJZ-286 can be used for immunoassay techniques such as: ELISA, FC, WB.
See all TRIP6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJZ-286
Antibody Isotype
IgG1
Application
ELISA, FC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL

Target

Full Name
TRIP6 Thyroid Hormone Receptor Interactor 6
Introduction
TRIP6 (Thyroid Hormone Receptor Interactor 6) is a Protein Coding gene. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Among its related pathways are Toll-like receptor signaling pathway and LPA receptor mediated events. Gene Ontology (GO) annotations related to this gene include thyroid hormone receptor binding. An important paralog of this gene is LPP.
Entrez Gene ID
7205
UniProt ID
Q15654
Alternative Names
OIP1; OIP-1; ZRP-1; TRIP-6; TRIP6i2
Function
Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.
Biological Process
Biological Process chordate embryonic development Source:Ensembl
Biological Process focal adhesion assembly Source:UniProtKB1 Publication
Biological Process positive regulation of cell migration Source:UniProtKB1 Publication
Biological Process positive regulation of NIK/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process signal transduction Source:GO_Central1 Publication
Cellular Location
Cytoplasm, cytoskeleton
Cell junction, focal adhesion
Nucleus
Cytoplasm
Shuttles between nucleus and cytoplasm (PubMed:16624523).
Colocalizes with actin (PubMed:10826496).
PTM
Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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