TSGA10

TSGA10 (Testis Specific 10 Interacting Protein) is a Protein Coding gene. It functions in cell projection assembly, spermatogenesis.

Full Name

testis specific, 10

Function

Plays a role in spermatogenesis (PubMed:28905369).
When overexpressed, prevents nuclear localization of HIF1A (By similarity).

Biological Process

Biological Process spermatogenesis Source:UniProtKB1 Publication

Cellular Location

Cytoplasm
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
In mature spermatozoa, localizes to the centriole and midpiece (PubMed:28905369).
The 27-kDa peptide associates with the fibrous sheath in mature spermatozoa and localizes to the principal piece of sperm tail, while the 55-kDa peptide localizes to the midpiece (By similarity).
Detected in the cytoplasm of almost all spermatogonial cells within the seminiferous tubules (By similarity).

Involvement in disease

Spermatogenic failure 26 (SPGF26):
An autosomal recessive infertility disorder caused by spermatogenesis defects that result in acephalic spermatozoa.

PTM

Processed into N-terminal 27-kDa and C-terminal 55-kDa fragments.