TUFM

This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008]
Full Name
TUFM Gene(Protein Coding) Tu Translation Elongation Factor, Mitochondrial
Function
Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.
Biological Process
Biological Process mitochondrial translational elongation Source:GO_Central1 Publication
Biological Process response to ethanol Source:Ensembl
Biological Process translational elongation Source:UniProtKB1 Publication
Cellular Location
Mitochondrion
Involvement in disease
Mitochondrion:
A mitochondrial disease resulting in neonatal lactic acidosis, rapidly progressive encephalopathy, severely decreased mitochondrial protein synthesis, and combined deficiency of mtDNA-related mitochondrial respiratory chain complexes.
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Anti-TUFM antibodies

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TUFM Matched Antibody Pair (1285) (APMAB-1285LY)

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Target: TUFM
Specificity: Human
Datasheet SDS

Mouse Anti-TUFM Recombinant Antibody (3C1) (CBMAB-A9650-LY)

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Target: TUFM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3C1
Application*: WB, E
Datasheet SDS

Mouse Anti-TUFM Recombinant Antibody (V2-619096) (CBMAB-A9649-LY)

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Target: TUFM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-619096
Application*: SE, E
Datasheet SDS

Recombinant Mouse Anti-TUFM Recombinant Antibody (CBYC-XB007) (CBMAB-XB1191-YC)

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Target: TUFM
Host: Mouse
Specificity: Human
Clone: CBYC-XB007
Application*: WB
Datasheet SDS

Mouse Anti-TUFM Recombinant Antibody (CBYJT-5374) (CBMAB-T4975-YJ)

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Target: TUFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5374
Application*: WB, IH, IC, IF
Datasheet SDS

Mouse Anti-TUFM Recombinant Antibody (CBYJT-5373) (CBMAB-T4974-YJ)

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Target: TUFM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-5373
Application*: WB, IH, IC, IF
Datasheet SDS

Mouse Anti-TUFM Recombinant Antibody (CBYJT-5372) (CBMAB-T4973-YJ)

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Target: TUFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5372
Application*: WB, IH, IC, IF
Datasheet SDS

Mouse Anti-TUFM Recombinant Antibody (CBYJT-5371) (CBMAB-T4972-YJ)

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Target: TUFM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-5371
Application*: E
Datasheet SDS

Mouse Anti-TUFM Recombinant Antibody (CBYJT-5370) (CBMAB-T4971-YJ)

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Target: TUFM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-5370
Application*: E, IP, WB
Datasheet SDS

Rabbit Anti-TUFM Recombinant Antibody (CBYJT-5369) (CBMAB-T4970-YJ)

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Target: TUFM
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-5369
Application*: IC, IF
Datasheet SDS

Mouse Anti-TUFM Recombinant Antibody (CBFYE-1679) (CBMAB-E2351-FY)

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Target: TUFM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-1679
Application*: E, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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