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TUFM

This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008]
Full Name
TUFM Gene(Protein Coding) Tu Translation Elongation Factor, Mitochondrial
Function
Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.
Biological Process
Biological Process mitochondrial translational elongation Source:GO_Central1 Publication
Biological Process response to ethanol Source:Ensembl
Biological Process translational elongation Source:UniProtKB1 Publication
Cellular Location
Mitochondrion
Involvement in disease
Mitochondrion:
A mitochondrial disease resulting in neonatal lactic acidosis, rapidly progressive encephalopathy, severely decreased mitochondrial protein synthesis, and combined deficiency of mtDNA-related mitochondrial respiratory chain complexes.

Anti-TUFM antibodies

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Recombinant Mouse Anti-TUFM Recombinant Antibody (CBYC-XB007) (CBMAB-XB1191-YC)

Datasheet SDS
Target: TUFM
Host: Mouse
Specificity: Human
Clone: CBYC-XB007
Application*: WB

Rabbit Anti-TUFM Recombinant Antibody (CBYJT-5369) (CBMAB-T4970-YJ)

Datasheet SDS
Target: TUFM
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-5369
Application*: IC, IF

Mouse Anti-TUFM Recombinant Antibody (CBYJT-5370) (CBMAB-T4971-YJ)

Datasheet SDS
Target: TUFM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-5370
Application*: E, IP, WB

Mouse Anti-TUFM Recombinant Antibody (CBYJT-5371) (CBMAB-T4972-YJ)

Datasheet SDS
Target: TUFM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-5371
Application*: E

Mouse Anti-TUFM Recombinant Antibody (CBYJT-5372) (CBMAB-T4973-YJ)

Datasheet SDS
Target: TUFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5372
Application*: WB, IH, IC, IF

Mouse Anti-TUFM Recombinant Antibody (CBYJT-5373) (CBMAB-T4974-YJ)

Datasheet SDS
Target: TUFM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-5373
Application*: WB, IH, IC, IF

Mouse Anti-TUFM Recombinant Antibody (CBYJT-5374) (CBMAB-T4975-YJ)

Datasheet SDS
Target: TUFM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5374
Application*: WB, IH, IC, IF

Mouse Anti-TUFM Recombinant Antibody (V2-619096) (CBMAB-A9649-LY)

Datasheet SDS
Target: TUFM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-619096
Application*: SE, E

Mouse Anti-TUFM Recombinant Antibody (3C1) (CBMAB-A9650-LY)

Datasheet SDS
Target: TUFM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3C1
Application*: WB, E

Mouse Anti-TUFM Recombinant Antibody (CBFYE-1679) (CBMAB-E2351-FY)

Datasheet SDS
Target: TUFM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-1679
Application*: E, IP, WB

TUFM Matched Antibody Pair (1285) (APMAB-1285LY)

Datasheet SDS
Target: TUFM
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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