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Mouse Anti-TUFM Recombinant Antibody (CBYJT-5370) (CBMAB-T4971-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TUFM (Tu Translation Elongation Factor, Mitochondrial). The antibody can be used for immunoassay techniques, such as ELISA, IP, WB.
See all TUFM antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5370
Antibody Isotype
IgG1, κ
Application
ELISA, IP, WB

Basic Information

Immunogen
TUFM (AAH01633, 40 a.a. ~ 455 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: PLLCRGLAVE AKKTYVRDKP HVNVGTIGHV DHGKTTLTAA TTKILAEGGG AKFKKYEEID NAPEERARGI TINAAHVEYS TAARHYAHTD CPGHADYVKN MITGTAPLDG CILVVAANDG PMPQTREHLL LARQIGVEHV VVYVNKADAV QDSEMVELVE LEIRELLTEF GYKGEETPVI VGSALCALEG RDPELGLKSV QKLLDAVDTY IPVPARDLEK PFLLPVEAVY SVPGRGTVVT GTLERGILKK GDECELLGHS KNIRTVVTGI EMFHKSLERA EAGDNLGALV RGLKREDLRR GLVMVKPGSI KPHQKVEAQV YILSKEEGGR HKPFVSHFMP VMFSLTWDMA CRIILPPEKE LAMPGEDLKF NLILRQPMIL EKGQRFTLRD GNRTIGTGLV TNTLAMTEEE KNIKWG
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 40-455

Target

Full Name
TUFM Gene(Protein Coding) Tu Translation Elongation Factor, Mitochondrial
Introduction
TUFM is a protein which participates in protein translation in mitochondria. Mutations in TUFM have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy.
Entrez Gene ID
7284
UniProt ID
P49411
Alternative Names
Tu Translation Elongation Factor, Mitochondrial; EF-Tu; P43; Elongation Factor Tu, Mitochondrial; EF-TuMT; COXPD4; EFTU
Function
Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.
Biological Process
Biological Process mitochondrial translational elongation Source:GO_Central1 Publication
Biological Process response to ethanol Source:Ensembl
Biological Process translational elongation Source:UniProtKB1 Publication
Cellular Location
Mitochondrion
Involvement in disease
Mitochondrion:
A mitochondrial disease resulting in neonatal lactic acidosis, rapidly progressive encephalopathy, severely decreased mitochondrial protein synthesis, and combined deficiency of mtDNA-related mitochondrial respiratory chain complexes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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