Search : Keywords Target

loading...

Welcome Sign in or Don't have an account?Register

UBA2

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]

Full Name

ubiquitin like modifier activating enzyme 2

Function

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

Biological Process

Biological Process positive regulation of protein sumoylation Source:UniProtKB1 Publication
Biological Process protein modification by small protein conjugation Source:GO_Central1 Publication
Biological Process protein sumoylation Source:UniProtKB1 Publication

Cellular Location

Cytoplasm
Nucleus
Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.

PTM

Sumoylated with SUMO1 and SUMO2/3 and by UBC9. Sumoylation at Lys-236 inhibits enzymatic activity. Sumoylation at the C-terminal lysine cluster plays an essential role in nuclear trafficking.

Anti-UBA2 antibodies

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-UBA2 Recombinant Antibody (5B13) (CBMAB-BR485LY)

SDS

Target: UBA2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: 5B13

Application*: IHC-P, WB

Mouse Anti-UBA2 Recombinant Antibody (5H11) (CBMAB-BR484LY)

SDS

Target: UBA2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: 5H11

Application*: FC, WB

Rabbit Anti-UBA2 Recombinant Antibody (CBXS-1391) (CBMAB-S4249-CQ)

SDS

Target: UBA2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBXS-1391

Application*: WB, IP, P, IF

Mouse Anti-UBA2 Recombinant Antibody (CBXS-4966) (CBMAB-S2188-CQ)

SDS

Target: UBA2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Rat, Dog

Clone: CBXS-4966

Application*: WB, IH, IF, P

Rabbit Anti-UBA2 Recombinant Antibody (CBFYU-024) (CBMAB-U0024-FY)

SDS

Target: UBA2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey, Frog, Zebrafish, Cattle, Dog, Horse

Clone: CBFYU-024

Application*: WB, IP

Mouse Anti-UBA2 Recombinant Antibody (CBFYU-023) (CBMAB-U0023-FY)

SDS

Target: UBA2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Dog, Rat, Monkey

Clone: CBFYU-023

Application*: WB, IH, IF

Mouse Anti-UBA2 Recombinant Antibody (CBFYU-022) (CBMAB-U0022-FY)

SDS

Target: UBA2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Dog, Rat, Monkey

Clone: CBFYU-022

Application*: IF, IH, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

Online Inquiry