UBA2

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
Full Name
ubiquitin like modifier activating enzyme 2
Function
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Biological Process
Biological Process positive regulation of protein sumoylation Source:UniProtKB1 Publication
Biological Process protein modification by small protein conjugation Source:GO_Central1 Publication
Biological Process protein sumoylation Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Nucleus
Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.
PTM
Sumoylated with SUMO1 and SUMO2/3 and by UBC9. Sumoylation at Lys-236 inhibits enzymatic activity. Sumoylation at the C-terminal lysine cluster plays an essential role in nuclear trafficking.
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Anti-UBA2 antibodies

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Rabbit Anti-UBA2 Recombinant Antibody (CBFYU-024) (CBMAB-U0024-FY)

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Target: UBA2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Frog, Zebrafish, Cattle, Dog, Horse
Clone: CBFYU-024
Application*: WB, IP
Datasheet SDS

Mouse Anti-UBA2 Recombinant Antibody (5B13) (CBMAB-BR485LY)

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Target: UBA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 5B13
Application*: IHC-P, WB
Datasheet SDS

Mouse Anti-UBA2 Recombinant Antibody (5H11) (CBMAB-BR484LY)

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Target: UBA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 5H11
Application*: FC, WB
Datasheet SDS

Rabbit Anti-UBA2 Recombinant Antibody (CBXS-1391) (CBMAB-S4249-CQ)

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Target: UBA2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1391
Application*: WB, IP, P, IF
Datasheet SDS

Mouse Anti-UBA2 Recombinant Antibody (CBXS-4966) (CBMAB-S2188-CQ)

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Target: UBA2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat, Dog
Clone: CBXS-4966
Application*: WB, IH, IF, P
Datasheet SDS

Mouse Anti-UBA2 Recombinant Antibody (CBFYU-023) (CBMAB-U0023-FY)

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Target: UBA2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Rat, Monkey
Clone: CBFYU-023
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-UBA2 Recombinant Antibody (CBFYU-022) (CBMAB-U0022-FY)

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Target: UBA2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Rat, Monkey
Clone: CBFYU-022
Application*: IF, IH, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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