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Mouse Anti-UBA2 Recombinant Antibody (CBXS-4966) (CBMAB-S2188-CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Rat, Dog
Clone
CBXS-4966
Antibody Isotype
IgG2a
Application
WB, IHC, IF, IHC-P

Basic Information

Immunogen
Recombinant full length human UBA2 (NP_005490)
Specificity
Human, Rat, Dog
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ubiquitin like modifier activating enzyme 2
Introduction
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).
Entrez Gene ID
Human10054
Rat308508
Dog476490
UniProt ID
HumanQ9UBT2
RatF1LS72
DogA0A8C0M2R3
Alternative Names
Ubiquitin Like Modifier Activating Enzyme 2; Anthracycline-Associated Resistance ARX; Ubiquitin-Like 1-Activating Enzyme E1B; SUMO1 Activating Enzyme Subunit 2; SAE2; UBA2, Ubiquitin-Activating Enzyme E1 Homolog (Yeast); UBA2, Ubiquitin-Activating Enzyme E1 Homolog; Ubiquitin-Like Modifier Activating Enzyme 2; Ubiquitin-Like Modifier-Activating Enzyme 2;
Function
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Biological Process
Biological Process positive regulation of protein sumoylation Source:UniProtKB1 Publication
Biological Process protein modification by small protein conjugation Source:GO_Central1 Publication
Biological Process protein sumoylation Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Nucleus
Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.
PTM
Sumoylated with SUMO1 and SUMO2/3 and by UBC9. Sumoylation at Lys-236 inhibits enzymatic activity. Sumoylation at the C-terminal lysine cluster plays an essential role in nuclear trafficking.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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