Rabbit Anti-UBA2 Recombinant Antibody (CBXS-1391) (CBMAB-S4249-CQ)

Name: Rabbit Anti-UBA2 Recombinant Antibody (CBXS-1391)
SKU: CBMAB-S4249-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBXS-1391

Application

WB, IP, IHC-P, IF

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

0.973 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

ubiquitin like modifier activating enzyme 2

Introduction

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).

Entrez Gene ID

Human	10054
Mouse	50995
Rat	308508

UniProt ID

Human	Q9UBT2
Mouse	Q9Z1F9
Rat	F1LS72

Alternative Names

Ubiquitin Like Modifier Activating Enzyme 2; Anthracycline-Associated Resistance ARX; Ubiquitin-Like 1-Activating Enzyme E1B; SUMO1 Activating Enzyme Subunit 2; SAE2; UBA2, Ubiquitin-Activating Enzyme E1 Homolog (Yeast); UBA2, Ubiquitin-Activating Enzyme E1 Homolog; Ubiquitin-Like Modifier Activating Enzyme 2; Ubiquitin-Like Modifier-Activating Enzyme 2;

Function

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

Biological Process

Biological Process positive regulation of protein sumoylation Source:UniProtKB1 Publication
Biological Process protein modification by small protein conjugation Source:GO_Central1 Publication
Biological Process protein sumoylation Source:UniProtKB1 Publication

Cellular Location

Cytoplasm
Nucleus
Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.

PTM

Sumoylated with SUMO1 and SUMO2/3 and by UBC9. Sumoylation at Lys-236 inhibits enzymatic activity. Sumoylation at the C-terminal lysine cluster plays an essential role in nuclear trafficking.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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