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Rabbit Anti-UBA2 Recombinant Antibody (CBFYU-024) (CBMAB-U0024-FY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Frog, Zebrafish, Cattle, Dog, Horse
Clone
CBFYU-024
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat, Monkey, Frog, Zebrafish, Cattle, Dog, Horse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ubiquitin like modifier activating enzyme 2
Introduction
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Entrez Gene ID
Human10054
Mouse50995
Rat308508
Monkey705808
Frog549845
Zebrafish406672
Cattle507005
Dog476490
Horse100057234
UniProt ID
HumanQ9UBT2
MouseQ9Z1F9
RatF1LS72
MonkeyF6TLE0
FrogQ28GH3
ZebrafishQ7SXG4
CattleA4FV12
DogA0A8C0M2R3
HorseF7CZK0
Alternative Names
ARX; SAE2; HRIHFB2115
Function
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Biological Process
Biological Process positive regulation of protein sumoylation Source:UniProtKB1 Publication
Biological Process protein modification by small protein conjugation Source:GO_Central1 Publication
Biological Process protein sumoylation Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Nucleus
Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.
PTM
Sumoylated with SUMO1 and SUMO2/3 and by UBC9. Sumoylation at Lys-236 inhibits enzymatic activity. Sumoylation at the C-terminal lysine cluster plays an essential role in nuclear trafficking.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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