USP44
The protein encoded by this gene is a protease that functions as a deubiquitinating enzyme. The encoded protein is thought to help regulate the spindle assembly checkpoint by preventing early anaphase onset.
Full Name
Ubiquitin specific peptidase 44
Function
Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.
Biological Process
Biological Process cell cycle Source:UniProtKB-KW
Biological Process cell division Source:UniProtKB-KW
Biological Process chromosome segregation Source:Ensembl
Biological Process negative regulation of ubiquitin protein ligase activity Source:UniProtKB1 Publication
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:UniProtKB
Biological Process protein deubiquitination Source:UniProtKB2 Publications
Biological Process regulation of mitotic cell cycle spindle assembly checkpoint Source:UniProtKB
Biological Process cell division Source:UniProtKB-KW
Biological Process chromosome segregation Source:Ensembl
Biological Process negative regulation of ubiquitin protein ligase activity Source:UniProtKB1 Publication
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:UniProtKB
Biological Process protein deubiquitination Source:UniProtKB2 Publications
Biological Process regulation of mitotic cell cycle spindle assembly checkpoint Source:UniProtKB
Cellular Location
Nucleus
Peaks in interphase, with relatively low levels maintained throughout mitosis.
Peaks in interphase, with relatively low levels maintained throughout mitosis.
PTM
Dephosphorylated by CTDP1.
Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination and is degraded by the proteasome.
Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination and is degraded by the proteasome.
View more
Anti-USP44 antibodies
+ Filters
Target: USP44
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYU-258
Application*: SE, E, WB, IF
Target: USP44
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F2
Application*: WB
Target: USP44
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5C4
Application*: WB
Target: USP44
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5B8
Application*: WB
Target: USP44
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4E8
Application*: WB
Target: USP44
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F9
Application*: IH, WB
Target: USP44
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D7
Application*: WB
Target: USP44
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D6
Application*: WB
Target: USP44
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1D1
Application*: P, WB
Target: USP44
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1C2
Application*: WB
Target: USP44
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1A9
Application*: IH, WB
More Infomation
Hot products 
-
Rat Anti-C5AR1 Recombinant Antibody (8D6) (CBMAB-C9139-LY)
-
Mouse Anti-AKR1B1 Antibody (V2-2449) (CBMAB-1001CQ)
-
Mouse Anti-Acetyl SMC3 (K105/K106) Recombinant Antibody (V2-634053) (CBMAB-AP052LY)
-
Rabbit Anti-ABL1 (Phosphorylated Y245) Recombinant Antibody (V2-505716) (PTM-CBMAB-0465LY)
-
Mouse Anti-GLP1R Recombinant Antibody (4F3) (CBMAB-G0521-LY)
-
Rabbit Anti-ENO2 Recombinant Antibody (BA0013) (CBMAB-0272CQ)
-
Rat Anti-CD300A Recombinant Antibody (172224) (CBMAB-C0423-LY)
-
Mouse Anti-ARSA Recombinant Antibody (CBYC-A799) (CBMAB-A3679-YC)
-
Mouse Anti-CALR Recombinant Antibody (CBFYC-0763) (CBMAB-C0818-FY)
-
Mouse Anti-G6PD Recombinant Antibody (13B331) (CBMAB-G1553-LY)
-
Rat Anti-ABCC11 Recombinant Antibody (V2-179001) (CBMAB-A0236-YC)
-
Mouse Anti-ARHGAP5 Recombinant Antibody (54/P190-B) (CBMAB-P0070-YC)
-
Mouse Anti-ABIN2 Recombinant Antibody (V2-179106) (CBMAB-A0349-YC)
-
Mouse Anti-EIF4G1 Recombinant Antibody (2A9) (CBMAB-A2544-LY)
-
Mouse Anti-C4B Recombinant Antibody (CBYY-C2996) (CBMAB-C4439-YY)
-
Mouse Anti-APC Recombinant Antibody (CBYC-A661) (CBMAB-A3036-YC)
-
Rabbit Anti-BAD (Phospho-Ser136) Recombinant Antibody (CAP219) (CBMAB-AP536LY)
-
Mouse Anti-CFL1 Recombinant Antibody (CBFYC-1771) (CBMAB-C1833-FY)
-
Mouse Anti-ALB Recombinant Antibody (V2-180650) (CBMAB-A2186-YC)
-
Rabbit Anti-ALOX5AP Recombinant Antibody (CBXF-1219) (CBMAB-F0750-CQ)
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
Online Inquiry