USP44

The protein encoded by this gene is a protease that functions as a deubiquitinating enzyme. The encoded protein is thought to help regulate the spindle assembly checkpoint by preventing early anaphase onset.
Full Name
Ubiquitin specific peptidase 44
Function
Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.
Biological Process
Biological Process cell cycle Source:UniProtKB-KW
Biological Process cell division Source:UniProtKB-KW
Biological Process chromosome segregation Source:Ensembl
Biological Process negative regulation of ubiquitin protein ligase activity Source:UniProtKB1 Publication
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:UniProtKB
Biological Process protein deubiquitination Source:UniProtKB2 Publications
Biological Process regulation of mitotic cell cycle spindle assembly checkpoint Source:UniProtKB
Cellular Location
Nucleus
Peaks in interphase, with relatively low levels maintained throughout mitosis.
PTM
Dephosphorylated by CTDP1.
Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination and is degraded by the proteasome.
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Anti-USP44 antibodies

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Mouse Anti-USP44 Recombinant Antibody (CBFYU-258) (CBMAB-U0258-FY)

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Target: USP44
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYU-258
Application*: SE, E, WB, IF
Datasheet SDS

Mouse Anti-USP44 (aa 420-712) Recombinant Antibody (5F2) (CBMAB-U0098-CQ)

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Target: USP44
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F2
Application*: WB
Datasheet SDS

Mouse Anti-USP44 (aa 420-712) Recombinant Antibody (5C4) (CBMAB-U0092-CQ)

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Target: USP44
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5C4
Application*: WB
Datasheet SDS

Mouse Anti-USP44 (aa 420-712) Recombinant Antibody (5B8) (CBMAB-U0090-CQ)

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Target: USP44
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5B8
Application*: WB
Datasheet SDS

Mouse Anti-USP44 (aa 420-712) Recombinant Antibody (4E8) (CBMAB-U0082-CQ)

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Target: USP44
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4E8
Application*: WB
Datasheet SDS

Mouse Anti-USP44 (aa 420-712) Recombinant Antibody (1F9) (CBMAB-U0036-CQ)

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Target: USP44
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F9
Application*: IH, WB
Datasheet SDS

Mouse Anti-USP44 (aa 420-712) Recombinant Antibody (1D7) (CBMAB-U0027-CQ)

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Target: USP44
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D7
Application*: WB
Datasheet SDS

Mouse Anti-USP44 (aa 420-712) Recombinant Antibody (1D6) (CBMAB-U0026-CQ)

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Target: USP44
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D6
Application*: WB
Datasheet SDS

Mouse Anti-USP44 (aa 420-712) Recombinant Antibody (1D1) (CBMAB-U0024-CQ)

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Target: USP44
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1D1
Application*: P, WB
Datasheet SDS

Mouse Anti-USP44 (aa 420-712) Recombinant Antibody (1C2) (CBMAB-U0022-CQ)

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Target: USP44
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1C2
Application*: WB
Datasheet SDS

Mouse Anti-USP44 (aa 420-712) Recombinant Antibody (1A9) (CBMAB-U0017-CQ)

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Target: USP44
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1A9
Application*: IH, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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