WNT9B

WNT9B is a protein-coding gene. The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Diseases associated with WNT9B include Mayer-Rokitansky-Kuster-Hauser Syndrome and Exstrophy Of Bladder. An important paralog of this gene is WNT9A.

Full Name

Wnt family member 9B

Function

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males. Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis. Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (By similarity).

Biological Process

Biological Process branching involved in ureteric bud morphogenesis Source:Ensembl
Biological Process canonical Wnt signaling pathway Source:WormBase1 Publication
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cellular response to retinoic acid Source:UniProtKB
Biological Process cellular response to starvation Source:Ensembl
Biological Process collecting duct development Source:Ensembl
Biological Process cornea development in camera-type eye Source:BHF-UCLBy Similarity
Biological Process embryonic cranial skeleton morphogenesis Source:Ensembl
Biological Process establishment of planar polarity involved in nephron morphogenesis Source:Ensembl
Biological Process in utero embryonic development Source:Ensembl
Biological Process kidney rudiment formation Source:Ensembl
Biological Process male genitalia development Source:Ensembl
Biological Process mesenchymal stem cell maintenance involved in nephron morphogenesis Source:Ensembl
Biological Process mesonephric duct formation Source:Ensembl
Biological Process metanephric tubule formation Source:Ensembl
Biological Process midbrain dopaminergic neuron differentiation Source:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of stem cell population maintenance Source:ParkinsonsUK-UCL1 Publication
Biological Process neuron differentiation Source:UniProtKB
Biological Process non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of catalytic activity Source:Ensembl
Biological Process regulation of asymmetric cell division Source:Ensembl
Biological Process regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source:Ensembl
Biological Process regulation of protein phosphorylation Source:Ensembl
Biological Process regulation of tube size Source:Ensembl
Biological Process response to retinoic acid Source:BHF-UCL1 Publication
Biological Process roof of mouth development Source:Ensembl
Biological Process uterus morphogenesis Source:Ensembl
Biological Process Wnt signaling pathway, planar cell polarity pathway Source:Ensembl

Cellular Location

Secreted, extracellular space, extracellular matrix
Secreted

PTM

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.