ZP1

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene ensures the structural integrity of the zona pellucida. Mutations in this gene are a cause of oocyte maturation defect and infertility.

Full Name

zona pellucida glycoprotein 1

Function

Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.

Biological Process

Biological Process binding of sperm to zona pellucida Source:GO_Central1 Publication
Biological Process prevention of polyspermy Source:GO_Central1 Publication

Cellular Location

Processed zona pellucida sperm-binding protein 1
Zona pellucida
Cell membrane

Involvement in disease

Oocyte maturation defect 1 (OOMD1):
An infertility disorder caused by defective oocyte maturation that results in abnormal eggs lacking a zona pellucida. Affected females have normal menstrual cycles and sex hormone levels, no obstruction in the fallopian tubes or abnormalities of the uterus or adnexa.

Topology

Extracellular: 26-601
Helical: 602-622
Cytoplasmic: 623-638

Anti-ZP1 antibodies

Rabbit Anti-ZP1 Recombinant Antibody (CBWJZ-276) (CBMAB-Z0713-WJ)

Datasheet

SDS

Target: ZP1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJZ-276

Application*: WB

Rat Anti-ZP1 Recombinant Antibody (CBWJZ-277) (CBMAB-Z0714-WJ)

Datasheet

SDS

Target: ZP1

Host: Rat

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBWJZ-277

Application*: WB, IP

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)