ACO1 Matched Antibody Pair (005) (APMAB-005LY)

Name: ACO1 Matched Antibody Pair (005)
SKU: APMAB-005LY
Rating: 5 (1 reviews)

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Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-ACO1 monoclonal antibody, 100 ug

Detection Antibody

Anti-ACO1 Rabbit polyclonal antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014]

Alternative Names

Aconitase 1; Iron-Responsive Element-Binding Protein 1; Aconitate Hydratase, Cytoplasmic; Ferritin Repressor Protein; Iron Regulatory Protein 1; Cytosplasmic Aconitase; Aconitase 1, Soluble; Citrate Hydro-Lyase; Soluble Aconitase; EC 4.2.1.3; IRE-BP 1;

Entrez Gene ID

UniProt ID

P21399

More Infomation

References

Eprintsev, A. T., Fedorin, D. N., Cherkasskikh, M. V., & Igamberdiev, A. U. (2021). Effect of Salt Stress on the Expression and Promoter Methylation of the Genes Encoding the Mitochondrial and Cytosolic Forms of Aconitase and Fumarase in Maize. International Journal of Molecular Sciences, 22(11), 6012.

Eprintsev, A. T., Fedorin, D. N., Cherkasskikh, M. V., & Igamberdiev, A. U. (2020). Regulation of expression of the mitochondrial and cytosolic forms of aconitase in maize leaves via phytochrome. Plant Physiology and Biochemistry, 146, 157-162.

De Bellis, L., Luvisi, A., & Alpi, A. (2020). Aconitase: to be or not to be inside plant glyoxysomes, that is the question. Biology, 9(7), 162.

Chen, Y., Cai, G. H., Xia, B., Wang, X., Zhang, C. C., Xie, B. C., ... & Wu, J. W. (2020). Mitochondrial aconitase controls adipogenesis through mediation of cellular ATP production. The FASEB Journal, 34(5), 6688-6702.

Gonzalez-Sanchez, L., Cobos-Fernandez, M. A., Lopez-Nieva, P., Villa-Morales, M., Stamatakis, K., Cuezva, J. M., ... & Fernandez-Piqueras, J. (2020). Exploiting the passenger ACO1-deficiency arising from 9p21 deletions to kill T-cell lymphoblastic neoplasia cells. Carcinogenesis, 41(8), 1113-1122.

Oskarsson, G. R., Oddsson, A., Magnusson, M. K., Kristjansson, R. P., Halldorsson, G. H., Ferkingstad, E., ... & Stefansson, K. (2020). Predicted loss and gain of function mutations in ACO1 are associated with erythropoiesis. Communications biology, 3(1), 1-10.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Rabbit Anti-ACO1 Recombinant Antibody (V2-621657)

Mouse Anti-ACO1 Recombinant Antibody (V2-610925)

Mouse Anti-ACO1 Recombinant Antibody (V2-179324)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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