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Rabbit Anti-AATF Recombinant Antibody (V2-639280) (CBMAB-EN007-LY)

The product is antibody recognizes AATF . The antibody EG006 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:10000.
See all AATF antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
V2-639280
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from N-terminal of human AATF.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Apoptosis Antagonizing Transcription Factor
Introduction
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human26574
Mouse56321
Rat114512
UniProt ID
HumanQ9NY61
MouseQ9JKX4
RatQ9QYW0
Alternative Names
Apoptosis Antagonizing Transcription Factor; Rb-Binding Protein Che-1; CHE1; DED; Apoptosis-Antagonizing Transcription Factor; Protein AATF; CHE-1; BFR2;
Function
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Biological Process
Cell adhesion
Cellular response to DNA damage stimulus
Embryonic cleavage
Negative regulation of amyloid precursor protein biosynthetic process
Negative regulation of apoptotic process
Negative regulation of apoptotic signaling pathway
Negative regulation of reactive oxygen species metabolic process
Negative regulation of superoxide anion generation
Positive regulation of transcription by RNA polymerase II
Regulation of mitotic cell cycle
Regulation of transcription by RNA polymerase II
Ribosome biogenesis
Cellular Location
Nucleolus
PTM
Hyperphosphorylated during the G1/S phase transition.

Wang, W., Ma, Y. M., Jiang, Z. L., Gao, Z. W., & Chen, W. G. (2021). Apoptosis‑antagonizing transcription factor is involved in rat post‑traumatic epilepsy pathogenesis. Experimental and Therapeutic Medicine, 21(4), 1-1.

Srinivas, A. N., Suresh, D., Mirshahi, F., Santhekadur, P. K., Sanyal, A. J., & Kumar, D. P. (2021). Emerging roles of AATF: checkpoint signaling and beyond. Journal of Cellular Physiology, 236(5), 3383-3395.

Kumar, D. P., Santhekadur, P. K., Seneshaw, M., Mirshahi, F., Uram‐Tuculescu, C., & Sanyal, A. J. (2019). A regulatory role of apoptosis antagonizing transcription factor in the pathogenesis of nonalcoholic fatty liver disease and hepatocellular carcinoma. Hepatology, 69(4), 1520-1534.

Jain, M., Kaiser, R. W., Bohl, K., Hoehne, M., Göbel, H., Bartram, M. P., ... & Slaats, G. G. (2019). Inactivation of apoptosis antagonizing transcription factor in tubular epithelial cells induces accumulation of DNA damage and nephronophthisis. Kidney international, 95(4), 846-858.

Fratini, E., Cervelli, M., Mariottini, P., Kanamori, Y., Amendola, R., & Agostinelli, E. (2019). Link between spermine oxidase and apoptosis antagonizing transcription factor: A new pathway in neuroblastoma. International journal of oncology, 55(5), 1149-1156.

Benakanakere, M. R., Zhao, J., Finoti, L., Schattner, R., Odabas-Yigit, M., & Kinane, D. F. (2019). MicroRNA-663 antagonizes apoptosis antagonizing transcription factor to induce apoptosis in epithelial cells. Apoptosis, 24(1), 108-118.

Jing, P., Zou, J., Weng, K., & Peng, P. (2018). The PI 3K/AKT axis modulates AATF activity in Wilms’ tumor cells. FEBS Open bio, 8(10), 1615-1623.

Jain, M. (2018). Targeted deletion of the DNA damage response regulator Apoptosis Antagonizing Transcription Factor (AATF) in mice decelerates lung tumorigenesis and causes degenerative renal disease (Doctoral dissertation, Universität zu Köln).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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