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AATF

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]
Full Name
Apoptosis Antagonizing Transcription Factor
Function
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Biological Process
Cell adhesion
Cellular response to DNA damage stimulus
Embryonic cleavage
Negative regulation of amyloid precursor protein biosynthetic process
Negative regulation of apoptotic process
Negative regulation of apoptotic signaling pathway
Negative regulation of reactive oxygen species metabolic process
Negative regulation of superoxide anion generation
Positive regulation of transcription by RNA polymerase II
Regulation of mitotic cell cycle
Regulation of transcription by RNA polymerase II
Ribosome biogenesis
Cellular Location
Nucleolus
PTM
Hyperphosphorylated during the G1/S phase transition.

Anti-AATF antibodies

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Target: AATF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-178869
Application*: E, IF, IH, WB
Target: AATF
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: V2-178870
Application*: WB
Target: AATF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-178871
Application*: WB, IP
Target: AATF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: V2-639280
Application*: WB: 1:500~1:1000 ELISA: 1:10000
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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