AATF

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]

Full Name

Apoptosis Antagonizing Transcription Factor

Function

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

Biological Process

Cell adhesion
Cellular response to DNA damage stimulus
Embryonic cleavage
Negative regulation of amyloid precursor protein biosynthetic process
Negative regulation of apoptotic process
Negative regulation of apoptotic signaling pathway
Negative regulation of reactive oxygen species metabolic process
Negative regulation of superoxide anion generation
Positive regulation of transcription by RNA polymerase II
Regulation of mitotic cell cycle
Regulation of transcription by RNA polymerase II
Ribosome biogenesis

Cellular Location

Nucleolus

PTM

Hyperphosphorylated during the G1/S phase transition.