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Mouse Anti-ACTR3 Recombinant Antibody (CBT3868) (V2LY-0625-LY819)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBT3868
Antibody Isotype
IgG1
Application
WB, IHC, ICC

Basic Information

Immunogen
Purified recombinant fragment of human ACTR3 (AA: 287-418) expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ARP3 Actin Related Protein 3 Homolog
Entrez Gene ID
10096
UniProt ID
P61158
Function
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Plays a role in ciliogenesis.
Biological Process
Actin polymerization-dependent cell motility
Arp2/3 complex-mediated actin nucleation
Asymmetric cell division
Cellular response to interferon-gamma
Cilium assembly
Ephrin receptor signaling pathway
Establishment or maintenance of cell polarity
Fc-gamma receptor signaling pathway involved in phagocytosis
Meiotic chromosome movement towards spindle pole
Meiotic cytokinesis
Membrane organization
Positive regulation of lamellipodium assembly
Positive regulation of transcription by RNA polymerase II
Spindle localization
Cellular Location
Cytoskeleton; Nucleus; Cell projection. In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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