Human ACTR3 ELISA Kit (V2LY-0626-LY4202)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.012 ng/mL
Detection Range
0.02-4 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
47.4 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
ARP3 Actin Related Protein 3 Homolog
Function
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Plays a role in ciliogenesis.
Biological Process
Actin polymerization-dependent cell motility
Arp2/3 complex-mediated actin nucleation
Asymmetric cell division
Cellular response to interferon-gamma
Cilium assembly
Ephrin receptor signaling pathway
Establishment or maintenance of cell polarity
Fc-gamma receptor signaling pathway involved in phagocytosis
Meiotic chromosome movement towards spindle pole
Meiotic cytokinesis
Membrane organization
Positive regulation of lamellipodium assembly
Positive regulation of transcription by RNA polymerase II
Spindle localization
Cellular Location
Cytoskeleton; Nucleus; Cell projection. In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes).

Obeidy, P., Ju, L. A., Oehlers, S. H., Zulkhernain, N. S., Lee, Q., Galeano Niño, J. L., ... & Weninger, W. (2020). Partial loss of actin nucleator actin‐related protein 2/3 activity triggers blebbing in primary T lymphocytes. Immunology and cell biology, 98(2), 93-113.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant ACTR3 protein, GST Tag (CAT#: V2LY-0526-LY2174)

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Mouse Anti-ACTR3 Recombinant Antibody (V2-179661) (CAT#: CBMAB-A1014-YC)

Mouse Anti-ACTR3 Recombinant Antibody (V2-179660) (CAT#: CBMAB-A1013-YC)

Rabbit Anti-ACTR3 Recombinant Antibody (
7E5) (CAT#: V2LY-0725-LY1049)

Human Recombinant ACTR3 protein, GST Tag (CAT#: V2LY-0526-LY2174)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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