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Mouse Anti-ADAM12 Recombinant Antibody (V2-179751) (CBMAB-A1113-YC)

Provided herein is a Mouse monoclonal antibody against Human ADAM Metallopeptidase Domain 12. The antibody can be used for immunoassay techniques, such as IP.
See all ADAM12 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179751
Antibody Isotype
IgG1
Application
IP

Basic Information

Immunogen
Recombinant corresponding to Arg29-Ser513 from human ADAM12 expressed in CHO cells.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IP25 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, pH 7.4, 5% trehalose
Preservative
None
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ADAM Metallopeptidase Domain 12
Introduction
ADAM12 is a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle developmen
Entrez Gene ID
8038
UniProt ID
O43184
Alternative Names
ADAM Metallopeptidase Domain 12; Meltrin-Alpha; MLTN; Disintegrin And Metalloproteinase Domain-Containing Protein 12; A Disintegrin And Metalloproteinase Domain 12 (Meltrin Alpha); Metalloprotease-Disintegrin 12 Transmembrane; Meltrin Alpha; EC 3.4.24.58;
Function
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).
Biological Process
Cell adhesion
Extracellular matrix organization
Myoblast fusion
Positive regulation of angiogenesis
Cellular Location
Isoform 1: Cell membrane
Isoform 2: Secreted
Isoform 3: Secreted
Isoform 4: Secreted
Topology
Extracellular: 208-708 aa
Helical: 709-729 aa
Cytoplasmic: 730-909 aa
PTM
The precursor is cleaved by a furin endopeptidase.

Mohamad, A., Hassan, R., Azlan Husin, M. F. J., & Sulong, S. (2021). Aberrant Methylation of Tumour Suppressor Gene ADAM12 in Chronic Lympocytic Leukemia Patients: Application of Methylation Specific-PCR Technique. Asian Pacific Journal of Cancer Prevention: APJCP, 22(1), 85.

Wang, L., Tan, Z., Zhang, Y., Kady Keita, N., Liu, H., & Zhang, Y. (2020). ADAM12 silencing promotes cellular apoptosis by activating autophagy in choriocarcinoma cells. International journal of oncology, 56(5), 1162-1174.

Bernstein, H. G., Keilhoff, G., Dobrowolny, H., Lendeckel, U., & Steiner, J. (2020). From putative brain tumor marker to high cognitive abilities: Emerging roles of a disintegrin and metalloprotease (ADAM) 12 in the brain. Journal of Chemical Neuroanatomy, 101846.

Aguilar Muniz, L. S., Gonzalez Galarza, F. F., Arguello Astorga, R., Prieto Hinojosa, A. I., Hernandez Teran, F., Mendez Hernandez, A., ... & Arellano Pérez Vertti, R. D. (2020). Analyses of the Genetic Polymorphisms rs3740199 and rs1871054 of the ADAM12 Gene and the Alleles at the rs2073508 Loci of the TGFB1 Gene and Their Contribution to Susceptibility to Primary Knee Osteoarthritis. Genetic testing and molecular biomarkers, 24(6), 375-380.

Albrechtsen, R., Wewer Albrechtsen, N. J., Gnosa, S., Schwarz, J., Dyrskjøt, L., & Kveiborg, M. (2019). Identification of ADAM12 as a novel basigin sheddase. International journal of molecular sciences, 20(8), 1957.

Xiong, L., Yan, W., Zubia, E., Zhou, Y., Zhang, Y., Duan, Q., ... & Xu, G. (2018). Quantitative proteomics and biochemical analyses reveal the role of endoplasmin in the regulation of the expression and secretion of A Disintegrin And Metalloproteinase 12. Journal of proteomics, 182, 34-44.

Hu, X., Sun, G., & Wang, W. (2017). Association of ADAM 12 polymorphisms with the risk of knee osteoarthritis: meta-analysis of 5048 cases and 6848 controls. Rheumatology international, 37(10), 1659-1666.

Wu, Z., Xu, X. W., & Zhang, X. W. (2017). The association of ADAM12 polymorphism with osteoarthritis susceptibility: a meta-analysis. Therapeutics and clinical risk management, 13, 821.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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