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ADAM12

This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]

Full Name

ADAM Metallopeptidase Domain 12

Function

Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).

Biological Process

Cell adhesion
Extracellular matrix organization
Myoblast fusion
Positive regulation of angiogenesis

Cellular Location

Isoform 1: Cell membrane
Isoform 2: Secreted
Isoform 3: Secreted
Isoform 4: Secreted

Topology

Extracellular: 208-708 aa
Helical: 709-729 aa
Cytoplasmic: 730-909 aa

PTM

The precursor is cleaved by a furin endopeptidase.

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Anti-ADAM12 antibodies

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Mouse Anti-ADAM12 Recombinant Antibody (V2-179752) (CBMAB-A1114-YC)

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Target: ADAM12

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: V2-179752

Application*: E, WB, IP

Mouse Anti-ADAM12 Recombinant Antibody (V2-179751) (CBMAB-A1113-YC)

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Target: ADAM12

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: V2-179751

Application*: IP

Rabbit Anti-ADAM12 Recombinant Antibody (V2-179754) (CBMAB-A1116-YC)

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Target: ADAM12

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: V2-179754

Application*: WB

Mouse Anti-ADAM12 Recombinant Antibody (V2-179753) (CBMAB-A1115-YC)

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Target: ADAM12

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: V2-179753

Application*: E, WB

Mouse Adam12 ELISA Kit (V2LY-0626-LY2313)

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Target: Adam12

Sensitivity: 0.024 ng/mL

Detection Range: 0.05-20 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Mouse

Assay Type: Sandwich

Reactivity: Mouse

Human Recombinant ADAM12 protein, His Tag (V2LY-0526-LY1934)

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Target: ADAM12

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-513

Tag: His Tag

ADAM12 Matched Antibody Pair (024) (APMAB-024LY)

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Target: ADAM12

Specificity: Human

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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