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ADAM12

This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]
Full Name
ADAM Metallopeptidase Domain 12
Function
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).
Biological Process
Cell adhesion
Extracellular matrix organization
Myoblast fusion
Positive regulation of angiogenesis
Cellular Location
Isoform 1: Cell membrane
Isoform 2: Secreted
Isoform 3: Secreted
Isoform 4: Secreted
Topology
Extracellular: 208-708 aa
Helical: 709-729 aa
Cytoplasmic: 730-909 aa
PTM
The precursor is cleaved by a furin endopeptidase.
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Anti-ADAM12 antibodies

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Mouse Anti-ADAM12 Recombinant Antibody (V2-179752) (CBMAB-A1114-YC)

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Target: ADAM12
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: V2-179752
Application*: E, WB, IP
Datasheet SDS

Mouse Anti-ADAM12 Recombinant Antibody (V2-179751) (CBMAB-A1113-YC)

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Target: ADAM12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179751
Application*: IP
Datasheet SDS

Rabbit Anti-ADAM12 Recombinant Antibody (V2-179754) (CBMAB-A1116-YC)

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Target: ADAM12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-179754
Application*: WB
Datasheet SDS

Mouse Anti-ADAM12 Recombinant Antibody (V2-179753) (CBMAB-A1115-YC)

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Target: ADAM12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179753
Application*: E, WB
Datasheet SDS

ADAM12 Matched Antibody Pair (024) (APMAB-024LY)

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Target: ADAM12
Specificity: Human
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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