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Mouse Anti-ADK Recombinant Antibody (V2-179985) (CBMAB-A1371-YC)

Provided herein is a Mouse monoclonal antibody against Human Adenosine Kinase. The antibody can be used for immunoassay techniques, such as ELISA.
See all ADK antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179985
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
ADK (NP_001114, 236 a.a. ~ 345 a.a) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Adenosine Kinase
Introduction
ADK catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervou
Entrez Gene ID
132
UniProt ID
P55263
Alternative Names
Adenosine Kinase; Adenosine 5-Phosphotransferase; EC 2.7.1.20; AK; Testicular Tissue Protein Li 14; EC 2.7.1;
Function
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
Biological Process
AMP salvage
dATP biosynthetic process
Purine-containing compound salvage
Purine ribonucleoside salvage
Ribonucleoside monophosphate biosynthetic process
Cellular Location
Isoform 1: Nucleus
Isoform 2: Cytoplasm
Involvement in disease
Hypermethioninemia due to adenosine kinase deficiency (HMAKD): A metabolic disorder characterized by global developmental delay, early-onset seizures, mild dysmorphic features, and characteristic biochemical anomalies, including persistent hypermethioninemia with increased levels of S-adenosylmethionine and S-adenosylhomocysteine. Homocysteine levels are typically normal.

Wang, Y., Xu, Y., Yan, S., Cao, K., Zeng, X., Zhou, Y., ... & Huo, Y. (2021). Adenosine kinase is critical for neointima formation after vascular injury by inducing aberrant DNA hypermethylation. Cardiovascular research, 117(2), 561-575.

Murugan, M., Fedele, D., Millner, D., Alharfoush, E., Vegunta, G., & Boison, D. (2021). Adenosine kinase: An epigenetic modulator in development and disease. Neurochemistry International, 147, 105054.

Becker, P. H., Demir, Z., Glassberg, Y. M., Sevin, C., Habes, D., Imbard, A., ... & Gaignard, P. (2021). Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia. Molecular Genetics and Metabolism, 132(1), 38-43.

Boison, D., & Jarvis, M. F. (2020). Adenosine kinase: A key regulator of purinergic physiology. Biochemical Pharmacology, 114321.

Moody, C. L., Funk, A. J., Devine, E., Devore Homan, R. C., Boison, D., McCullumsmith, R. E., & O’Donovan, S. M. (2020). Adenosine kinase expression in the frontal cortex in schizophrenia. Schizophrenia bulletin, 46(3), 690-698.

Gebril, H. M., Rose, R. M., Gesese, R., Emond, M. P., Huo, Y., Aronica, E., & Boison, D. (2020). Adenosine kinase inhibition promotes proliferation of neural stem cells after traumatic brain injury. Brain communications, 2(1), fcaa017.

Sandau, U. S., Yahya, M., Bigej, R., Friedman, J. L., Saleumvong, B., & Boison, D. (2019). Transient use of a systemic adenosine kinase inhibitor attenuates epilepsy development in mice. Epilepsia, 60(4), 615-625.

Cao, W., Yuan, Y., Liu, X., Li, Q., An, X., Huang, Z., ... & Xing, C. (2019). Adenosine kinase inhibition protects against cisplatin-induced nephrotoxicity. American Journal of Physiology-Renal Physiology, 317(1), F107-F115.

Zhang, M., Zeng, X., Yang, Q., Xu, J., Liu, Z., Zhou, Y., ... & Huo, Y. (2018). Ablation of myeloid ADK (adenosine kinase) epigenetically suppresses atherosclerosis in ApoE−/−(apolipoprotein E deficient) mice. Arteriosclerosis, thrombosis, and vascular biology, 38(12), 2780-2792.

Xu, Y., Wang, Y., Yan, S., Yang, Q., Zhou, Y., Zeng, X., ... & Huo, Y. (2017). Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation. Nature communications, 8(1), 1-16.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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