Human Recombinant ADK protein, GST Tag (V2LY-0526-LY1953)

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Basic Information

Expressed Host
Baculovirus-Insect Cells
Protein Species
Human
Tag
GST Tag
Protein Construction
This product is Human Recombinant ADK protein, GST Tag consist of Amino Acid: 1-345 and predicts a molecular mass of 68 kDa.
Molecule Mass
68 kDa
Sequence
Amino Acid: 1-345
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>90% as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Format
Liquid
Buffer
Tris, NaCl, Glycerol
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
Adenosine Kinase
Function
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
Biological Process
AMP salvage
dATP biosynthetic process
Purine-containing compound salvage
Purine ribonucleoside salvage
Ribonucleoside monophosphate biosynthetic process
Cellular Location
Isoform 1: Nucleus
Isoform 2: Cytoplasm
Involvement in disease
Hypermethioninemia due to adenosine kinase deficiency (HMAKD): A metabolic disorder characterized by global developmental delay, early-onset seizures, mild dysmorphic features, and characteristic biochemical anomalies, including persistent hypermethioninemia with increased levels of S-adenosylmethionine and S-adenosylhomocysteine. Homocysteine levels are typically normal.

Wang, Y., Xu, Y., Yan, S., Cao, K., Zeng, X., Zhou, Y., ... & Huo, Y. (2021). Adenosine kinase is critical for neointima formation after vascular injury by inducing aberrant DNA hypermethylation. Cardiovascular research, 117(2), 561-575.

Murugan, M., Fedele, D., Millner, D., Alharfoush, E., Vegunta, G., & Boison, D. (2021). Adenosine kinase: An epigenetic modulator in development and disease. Neurochemistry International, 147, 105054.

Becker, P. H., Demir, Z., Glassberg, Y. M., Sevin, C., Habes, D., Imbard, A., ... & Gaignard, P. (2021). Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia. Molecular Genetics and Metabolism, 132(1), 38-43.

Boison, D., & Jarvis, M. F. (2020). Adenosine kinase: A key regulator of purinergic physiology. Biochemical Pharmacology, 114321.

Moody, C. L., Funk, A. J., Devine, E., Devore Homan, R. C., Boison, D., McCullumsmith, R. E., & O’Donovan, S. M. (2020). Adenosine kinase expression in the frontal cortex in schizophrenia. Schizophrenia bulletin, 46(3), 690-698.

Gebril, H. M., Rose, R. M., Gesese, R., Emond, M. P., Huo, Y., Aronica, E., & Boison, D. (2020). Adenosine kinase inhibition promotes proliferation of neural stem cells after traumatic brain injury. Brain communications, 2(1), fcaa017.

Sandau, U. S., Yahya, M., Bigej, R., Friedman, J. L., Saleumvong, B., & Boison, D. (2019). Transient use of a systemic adenosine kinase inhibitor attenuates epilepsy development in mice. Epilepsia, 60(4), 615-625.

Cao, W., Yuan, Y., Liu, X., Li, Q., An, X., Huang, Z., ... & Xing, C. (2019). Adenosine kinase inhibition protects against cisplatin-induced nephrotoxicity. American Journal of Physiology-Renal Physiology, 317(1), F107-F115.

Zhang, M., Zeng, X., Yang, Q., Xu, J., Liu, Z., Zhou, Y., ... & Huo, Y. (2018). Ablation of myeloid ADK (adenosine kinase) epigenetically suppresses atherosclerosis in ApoE−/−(apolipoprotein E deficient) mice. Arteriosclerosis, thrombosis, and vascular biology, 38(12), 2780-2792.

Xu, Y., Wang, Y., Yan, S., Yang, Q., Zhou, Y., Zeng, X., ... & Huo, Y. (2017). Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation. Nature communications, 8(1), 1-16.

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For research use only. Not intended for any clinical use.

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