ADK

This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Full Name
Adenosine Kinase
Function
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
Biological Process
AMP salvage
dATP biosynthetic process
Purine-containing compound salvage
Purine ribonucleoside salvage
Ribonucleoside monophosphate biosynthetic process
Cellular Location
Isoform 1: Nucleus
Isoform 2: Cytoplasm
Involvement in disease
Hypermethioninemia due to adenosine kinase deficiency (HMAKD): A metabolic disorder characterized by global developmental delay, early-onset seizures, mild dysmorphic features, and characteristic biochemical anomalies, including persistent hypermethioninemia with increased levels of S-adenosylmethionine and S-adenosylhomocysteine. Homocysteine levels are typically normal.
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Anti-ADK antibodies

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Mouse Anti-ADK Recombinant Antibody (V2-634150) (CBMAB-AP170LY)

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Target: ADK
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: V2-634150
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-ADK Recombinant Antibody (V2-630612) (CBMAB-BR011LY)

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Target: ADK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-630612
Application*: WB, IHC-P, FC
Datasheet SDS

Mouse Anti-ADK Recombinant Antibody (V2-179987) (CBMAB-A1373-YC)

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Target: ADK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: V2-179987
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-ADK Recombinant Antibody (V2-179986) (CBMAB-A1372-YC)

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Target: ADK
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-179986
Application*: WB, F, E, IC, IF
Datasheet SDS

Mouse Anti-ADK Recombinant Antibody (V2-179985) (CBMAB-A1371-YC)

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Target: ADK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: V2-179985
Application*: E
Datasheet SDS

Mouse Anti-ADK Recombinant Antibody (V2-179984) (CBMAB-A1370-YC)

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Target: ADK
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: V2-179984
Application*: E, WB
Datasheet SDS

Human Recombinant ADK protein, GST Tag (V2LY-0526-LY1953)

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Target: ADK
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-345
Tag: GST Tag
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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