Mouse Anti-AEBP2 Recombinant Antibody (V2-180035) (CBMAB-A1441-YC)

Name: Mouse Anti-AEBP2 Recombinant Antibody (V2-180035)
SKU: CBMAB-A1441-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-180035

Application

ELISA, WB

Immunogen

AEBP2 Fusion Protein Ag17905 (1-295 aa).

Host Species

Mouse

Specificity

Human, Pig

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH7.3, 50% glycerol

Preservative

0.02% sodium azide

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

AE Binding Protein 2

Introduction

DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates Lys-9 and Lys-27 residues of histone H3.

Entrez Gene ID

121536

UniProt ID

Q6ZN18

Alternative Names

AE Binding Protein 2; Adipocyte Enhancer-Binding Protein 2; AE-Binding Protein 2;

Function

Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene. Plays a role in nucleosome localization of the PRC2 complex.

Biological Process

Chromatin organization
Negative regulation of gene expression, epigenetic
Regulation of transcription by RNA polymerase II

Cellular Location

Nucleus. Localizes to chromatin as part of the PRC2 complex.

Zhang, X., Cong, L., Xu, D., Leng, Q., Shi, M., & Zhou, Y. (2021). AC092127. 1-miR-451a-AE binding protein 2 Signaling Facilitates Malignant Properties of Breast Cancer. Journal of Breast Cancer, e37-e37.

Kasinath, V., Beck, C., Sauer, P., Poepsel, S., Kosmatka, J., Faini, M., ... & Nogales, E. (2021). JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications. Science, 371(6527).

Kasinath, V., Faini, M., Poepsel, S., Reif, D., Feng, X. A., Stjepanovic, G., ... & Nogales, E. (2018). Structures of human PRC2 with its cofactors AEBP2 and JARID2. Science, 359(6378), 940-944.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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