Mouse Anti-AEBP2 Recombinant Antibody (CBT4128) (V2LY-0625-LY619)

Name: Mouse Anti-AEBP2 Recombinant Antibody (CBT4128)
SKU: V2LY-0625-LY619
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBT4128

Antibody Isotype

IgG1

Application

WB, ICC, FC

Basic Information

Immunogen

Purified recombinant fragment of human AEBP2 (AA: 358-495) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
ICC	1:100-1:500
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

AE Binding Protein 2

Entrez Gene ID

121536

UniProt ID

Q6ZN18

Function

Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene. Plays a role in nucleosome localization of the PRC2 complex.

Biological Process

Chromatin organization
Negative regulation of gene expression, epigenetic
Regulation of transcription by RNA polymerase II

Cellular Location

Nucleus. Localizes to chromatin as part of the PRC2 complex.

More Infomation

References

Zhang, X., Cong, L., Xu, D., Leng, Q., Shi, M., & Zhou, Y. (2021). AC092127. 1-miR-451a-AE binding protein 2 Signaling Facilitates Malignant Properties of Breast Cancer. Journal of Breast Cancer, e37-e37.

Kasinath, V., Beck, C., Sauer, P., Poepsel, S., Kosmatka, J., Faini, M., ... & Nogales, E. (2021). JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications. Science, 371(6527).

Kasinath, V., Faini, M., Poepsel, S., Reif, D., Feng, X. A., Stjepanovic, G., ... & Nogales, E. (2018). Structures of human PRC2 with its cofactors AEBP2 and JARID2. Science, 359(6378), 940-944.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

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