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Mouse Anti-AHNAK Recombinant Antibody (V2-180274) (CBMAB-A1711-YC)

Provided herein is a Mouse monoclonal antibody against Human AHNAK Nucleoprotein. The antibody can be used for immunoassay techniques, such as ELISA, IP, WB.
See all AHNAK antibodies
Published Data
Fig.1 Immunoblots for AHNAK1.
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Fig.2 Immunofluorescence staining of AHNAK1 show diverse patterns in non-specifically and specifically stimulated T cells.
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Fig.3 Positive staining of AHNAK in grade 2 tumor.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-180274
Antibody Isotype
IgG2a, κ
Application
ELISA, IP, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa1-101 from human AHNAK (NP_076965) with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in PBS, pH 7.2
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
AHNAK Nucleoprotein
Introduction
AHNAK is a large (700 kDa) structural scaffold protein consisting of a central domain with 128 aa repeats. The encoded protein may play a role in such diverse processes as blood-brain barrier formation, cell structure and migration, cardiac calcium channe
Entrez Gene ID
79026
UniProt ID
Q09666
Alternative Names
AHNAK Nucleoprotein; Desmoyokin; PM227; Neuroblast Differentiation-Associated Protein AHNAK; AHNAK Nucleoprotein (Desmoyokin); AHNAK-Related; AHNAKRS;
Function
May be required for neuronal cell differentiation.
Biological Process
Regulation of RNA splicing
Regulation of voltage-gated calcium channel activity
Cellular Location
Nucleus

Kim, Y. N., Shin, J. H., Kyeong, D. S., Cho, S. Y., Kim, M. Y., Lim, H. J., ... & Seong, J. K. (2021). Ahnak deficiency attenuates high-fat diet-induced fatty liver in mice through FGF21 induction. Experimental & molecular medicine, 53(3), 468-482.

Cho, W. C., Jang, J. E., Kim, K. H., Yoo, B. C., & Ku, J. L. (2020). SORBS1 serves a metastatic role via suppression of AHNAK in colorectal cancer cell lines. International journal of oncology, 56(5), 1140-1151.

Zhang, Z., Liu, X., Huang, R., Liu, X., Liang, Z., & Liu, T. (2019). Upregulation of nucleoprotein AHNAK is associated with poor outcome of pancreatic ductal adenocarcinoma prognosis via mediating epithelial-mesenchymal transition. Journal of Cancer, 10(16), 3860.

Lee, H., Kim, K., Woo, J., Park, J., Kim, H., Lee, K. E., ... & Ryu, H. S. (2018). Quantitative proteomic analysis identifies AHNAK (neuroblast differentiation-associated protein AHNAK) as a novel candidate biomarker for bladder urothelial carcinoma diagnosis by liquid-based cytology. Molecular & Cellular Proteomics, 17(9), 1788-1802.

Zhao, Z., Xiao, S., Yuan, X., Yuan, J., Zhang, C., Li, H., ... & Liu, Q. (2017). AHNAK as a prognosis factor suppresses the tumor progression in glioma. Journal of Cancer, 8(15), 2924.

Chen, B., Wang, J., Dai, D., Zhou, Q., Guo, X., Tian, Z., ... & Xie, X. (2017). AHNAK suppresses tumour proliferation and invasion by targeting multiple pathways in triple-negative breast cancer. Journal of Experimental & Clinical Cancer Research, 36(1), 1-11.

Cho, W. C., Jang, J. E., & Ku, J. L. (2017). SORBS1-AHNAK complex regulates metastatic properties of cancer.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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