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Mouse Anti-AHNAK Recombinant Antibody (CBT4797) (V2LY-0625-LY1846)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4797
Antibody Isotype
IgG1
Application
IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human AHNAK (AA: 1-200) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
AHNAK Nucleoprotein
Entrez Gene ID
79026
UniProt ID
Q09666
Function
May be required for neuronal cell differentiation.
Biological Process
Regulation of RNA splicing
Regulation of voltage-gated calcium channel activity
Cellular Location
Nucleus
More Infomation

Kim, Y. N., Shin, J. H., Kyeong, D. S., Cho, S. Y., Kim, M. Y., Lim, H. J., ... & Seong, J. K. (2021). Ahnak deficiency attenuates high-fat diet-induced fatty liver in mice through FGF21 induction. Experimental & molecular medicine, 53(3), 468-482.

Cho, W. C., Jang, J. E., Kim, K. H., Yoo, B. C., & Ku, J. L. (2020). SORBS1 serves a metastatic role via suppression of AHNAK in colorectal cancer cell lines. International journal of oncology, 56(5), 1140-1151.

Zhang, Z., Liu, X., Huang, R., Liu, X., Liang, Z., & Liu, T. (2019). Upregulation of nucleoprotein AHNAK is associated with poor outcome of pancreatic ductal adenocarcinoma prognosis via mediating epithelial-mesenchymal transition. Journal of Cancer, 10(16), 3860.

Lee, H., Kim, K., Woo, J., Park, J., Kim, H., Lee, K. E., ... & Ryu, H. S. (2018). Quantitative proteomic analysis identifies AHNAK (neuroblast differentiation-associated protein AHNAK) as a novel candidate biomarker for bladder urothelial carcinoma diagnosis by liquid-based cytology. Molecular & Cellular Proteomics, 17(9), 1788-1802.

Zhao, Z., Xiao, S., Yuan, X., Yuan, J., Zhang, C., Li, H., ... & Liu, Q. (2017). AHNAK as a prognosis factor suppresses the tumor progression in glioma. Journal of Cancer, 8(15), 2924.

Chen, B., Wang, J., Dai, D., Zhou, Q., Guo, X., Tian, Z., ... & Xie, X. (2017). AHNAK suppresses tumour proliferation and invasion by targeting multiple pathways in triple-negative breast cancer. Journal of Experimental & Clinical Cancer Research, 36(1), 1-11.

Cho, W. C., Jang, J. E., & Ku, J. L. (2017). SORBS1-AHNAK complex regulates metastatic properties of cancer.

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For research use only. Not intended for any clinical use.

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