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Mouse Anti-AHSG Recombinant Antibody (V2-180304) (CBMAB-A1761-YC)

Provided herein is a Mouse monoclonal antibody against Human Alpha 2-HS Glycoprotein. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all AHSG antibodies
Published Data
Mouse Anti-AHSG Recombinant Antibody (5D8) (CBMAB-A1761-YC) in WB
Western blot analysis of AHSG, ApoD, AAP, VN, Hp and AAG was performed on seven serum samples. ...View More
Quaresima, B., Crugliano, T., Gaspari, M., Faniello, M. C., Cosimo, P., Valanzano, R., ... & Costanzo, F. (2008). A proteomics approach to identify changes in protein profiles in serum of Familial Adenomatous Polyposis patients. Cancer letters, 272(1), 40-52.

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-180304
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa 19-367 from human AHSG (AAH48198) with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in PBS, pH 7.2
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Alpha 2-HS Glycoprotein
Introduction
AHSG is a negatively-charged serum glycoprotein that is synthesized by hepatocytes. The encoded protein consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several processes, including
Entrez Gene ID
197
UniProt ID
P02765
Alternative Names
Alpha 2-HS Glycoprotein; Ba-Alpha-2-Glycoprotein; Alpha-2-Z-Globulin; Fetuin-A; FETUA; Alpha-2-HS-Glycoprotein;
Function
Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.
Biological Process
Acute-phase response Source: UniProtKB
Cellular protein metabolic process Source: Reactome
Negative regulation of bone mineralization Source: UniProtKB
Negative regulation of endopeptidase activity Source: GO_Central
Negative regulation of insulin receptor signaling pathway Source: UniProtKB
Neutrophil degranulation Source: Reactome
Pinocytosis Source: UniProtKB
Platelet degranulation Source: Reactome
Positive regulation of phagocytosis Source: UniProtKB
Post-translational protein modification Source: Reactome
Regulation of bone mineralization Source: UniProtKB
Regulation of inflammatory response Source: UniProtKB
Skeletal system development Source: UniProtKB
Cellular Location
Secreted
Involvement in disease
Alopecia-mental retardation syndrome 1 (APMR1): A rare autosomal recessive form of alopecia. APMR1 patients show loss of hair on the scalp, absence of eyebrows, eyelashes, axillary and pubic hair, and mild to severe mental retardation.
PTM
Phosphorylated by FAM20C in the extracellular medium.
O- and N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan at Asn-156: Hex5HexNAc4; N-glycan heterogeneity at Asn-176: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor).

Mancuso, E., Spiga, R., Rubino, M., Averta, C., Rotundo, S., Segura-Garcìa, C., ... & Andreozzi, F. (2021). Effects of Alpha-2-HS-glycoprotein on cognitive and emotional assessment in prediabetic and diabetic subjects. Journal of Affective Disorders, 282, 700-706.

Muzasti, R. A., Purwanto, B., & Sembiring, R. J. (2020). Is there an association between alpha 2-Heremans-Schmid glycoprotein (AHSG) gene Thr256Ser polymorphisms with aortic calcification in regular hemodialysis patients in Medan, Indonesia. Medicinski Glasnik, 17(2).

Roy, D., Fouzder, C., Mukhuty, A., Pal, S., Mondal, M. K., Kundu, R., & Chowdhury, P. (2019). Designed synthesis of dual emitting silicon quantum dot for cell imaging: direct labeling of alpha 2-HS-glycoprotein. Bioconjugate chemistry, 30(5), 1575-1583.

Lin, Y. H., Zhu, J., Meijer, S., Franc, V., & Heck, A. J. (2019). Glycoproteogenomics: A Frequent Gene Polymorphism Affects the Glycosylation Pattern of the Human Serum Fetuin/α-2-HS-Glycoprotein [S]. Molecular & Cellular Proteomics, 18(8), 1479-1490.

Heo, J. I., Yoon, D. W., Yu, J. H., Kim, N. H., Yoo, H. J., Seo, J. A., ... & Kim, N. H. (2018). Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha‐2‐HS‐glycoprotein. Journal of pineal research, 65(2), e12493.

Majek, P., Pecankova, K., Cermak, J., Gasova, Z., Prochazka, B., & Dyr, J. E. (2017). Alpha-2-HS-glycoprotein plasma level decrease correlates with age in patients with myelodysplastic syndromes. Cancer Biomarkers, 20(4), 637-639.

Kanno, T., Yasutake, K., Tanaka, K., Hadano, S., & Ikeda, J. E. (2017). A novel function of N-linked glycoproteins, alpha-2-HS-glycoprotein and hemopexin: Implications for small molecule compound-mediated neuroprotection. PLoS One, 12(10), e0186227.

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For research use only. Not intended for any clinical use.

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