Human Recombinant FETUA protein, His Tag (V2LY-0526-LY4050)

Name: Human Recombinant FETUA protein, His Tag
SKU: V2LY-0526-LY4050
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant FETUA protein, His Tag consist of Amino Acid: 1-367 and predicts a molecular mass of 38.8 kDa.

Molecule Mass

38.8 kDa

Verified

HPLC

Sequence

Amino Acid: 1-367

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥97% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Alpha 2-HS Glycoprotein

Function

Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.

Biological Process

Acute-phase response Source: UniProtKB
Cellular protein metabolic process Source: Reactome
Negative regulation of bone mineralization Source: UniProtKB
Negative regulation of endopeptidase activity Source: GO_Central
Negative regulation of insulin receptor signaling pathway Source: UniProtKB
Neutrophil degranulation Source: Reactome
Pinocytosis Source: UniProtKB
Platelet degranulation Source: Reactome
Positive regulation of phagocytosis Source: UniProtKB
Post-translational protein modification Source: Reactome
Regulation of bone mineralization Source: UniProtKB
Regulation of inflammatory response Source: UniProtKB
Skeletal system development Source: UniProtKB

Cellular Location

Secreted

Involvement in disease

Alopecia-mental retardation syndrome 1 (APMR1): A rare autosomal recessive form of alopecia. APMR1 patients show loss of hair on the scalp, absence of eyebrows, eyelashes, axillary and pubic hair, and mild to severe mental retardation.

PTM

Phosphorylated by FAM20C in the extracellular medium.
O- and N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan at Asn-156: Hex5HexNAc4; N-glycan heterogeneity at Asn-176: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor).

Mancuso, E., Spiga, R., Rubino, M., Averta, C., Rotundo, S., Segura-Garcìa, C., ... & Andreozzi, F. (2021). Effects of Alpha-2-HS-glycoprotein on cognitive and emotional assessment in prediabetic and diabetic subjects. Journal of Affective Disorders, 282, 700-706.

Muzasti, R. A., Purwanto, B., & Sembiring, R. J. (2020). Is there an association between alpha 2-Heremans-Schmid glycoprotein (AHSG) gene Thr256Ser polymorphisms with aortic calcification in regular hemodialysis patients in Medan, Indonesia. Medicinski Glasnik, 17(2).

Roy, D., Fouzder, C., Mukhuty, A., Pal, S., Mondal, M. K., Kundu, R., & Chowdhury, P. (2019). Designed synthesis of dual emitting silicon quantum dot for cell imaging: direct labeling of alpha 2-HS-glycoprotein. Bioconjugate chemistry, 30(5), 1575-1583.

Lin, Y. H., Zhu, J., Meijer, S., Franc, V., & Heck, A. J. (2019). Glycoproteogenomics: A Frequent Gene Polymorphism Affects the Glycosylation Pattern of the Human Serum Fetuin/α-2-HS-Glycoprotein [S]. Molecular & Cellular Proteomics, 18(8), 1479-1490.

Heo, J. I., Yoon, D. W., Yu, J. H., Kim, N. H., Yoo, H. J., Seo, J. A., ... & Kim, N. H. (2018). Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha‐2‐HS‐glycoprotein. Journal of pineal research, 65(2), e12493.

Majek, P., Pecankova, K., Cermak, J., Gasova, Z., Prochazka, B., & Dyr, J. E. (2017). Alpha-2-HS-glycoprotein plasma level decrease correlates with age in patients with myelodysplastic syndromes. Cancer Biomarkers, 20(4), 637-639.

Kanno, T., Yasutake, K., Tanaka, K., Hadano, S., & Ikeda, J. E. (2017). A novel function of N-linked glycoproteins, alpha-2-HS-glycoprotein and hemopexin: Implications for small molecule compound-mediated neuroprotection. PLoS One, 12(10), e0186227.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Recombinant AHSG protein, His Tag (CAT#: V2LY-0526-LY8311)

Cattle AHSG ELISA Kit (CAT#: V2LY-0626-LY2477)

Human AHSG ELISA Kit (CAT#: V2LY-0626-LY3899)

Rat Ahsg ELISA Kit (CAT#: V2LY-0626-LY987)

AHSG Matched Antibody Pair (038) (CAT#: APMAB-038LY)

AHSG Matched Antibody Pair (039) (CAT#: APMAB-039LY)

AHSG Matched Antibody Pair (040) (CAT#: APMAB-040LY)

Antibody Pairs

AHSG Matched Antibody Pair (038) (CAT#: APMAB-038LY)

AHSG Matched Antibody Pair (039) (CAT#: APMAB-039LY)

AHSG Matched Antibody Pair (040) (CAT#: APMAB-040LY)

Related Products

Rat Ahsg ELISA Kit (CAT#: V2LY-0626-LY987)

AHSG Matched Antibody Pair (038) (CAT#: APMAB-038LY)

Mouse Recombinant AHSG protein, His Tag (CAT#: V2LY-0526-LY8311)

Human AHSG ELISA Kit (CAT#: V2LY-0626-LY3899)

Mouse Anti-AHSG Recombinant Antibody (V2-162541) (CAT#: CBMAB-F2651-CQ)

Mouse Anti-AHSG Recombinant Antibody (V2-180305) (CAT#: CBMAB-A1762-YC)

Mouse Anti-AHSG Recombinant Antibody (V2-180308) (CAT#: CBMAB-A1765-YC)

Rat Anti-AHSG Recombinant Antibody (V2-162860) (CAT#: CBMAB-F3005-CQ)

Rabbit Anti-AHSG Recombinant Antibody (V2-160820) (CAT#: CBMAB-F0748-CQ)

AHSG Matched Antibody Pair (040) (CAT#: APMAB-040LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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