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AHSG

The protein encoded by this gene is a negatively-charged serum glycoprotein that is synthesized by hepatocytes. The encoded protein consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several processes, including endocytosis, brain development, and the formation of bone tissue. Defects in this gene are a cause of susceptibility to leanness. [provided by RefSeq, Aug 2017]
Full Name
Alpha 2-HS Glycoprotein
Function
Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.
Biological Process
Acute-phase response Source: UniProtKB
Cellular protein metabolic process Source: Reactome
Negative regulation of bone mineralization Source: UniProtKB
Negative regulation of endopeptidase activity Source: GO_Central
Negative regulation of insulin receptor signaling pathway Source: UniProtKB
Neutrophil degranulation Source: Reactome
Pinocytosis Source: UniProtKB
Platelet degranulation Source: Reactome
Positive regulation of phagocytosis Source: UniProtKB
Post-translational protein modification Source: Reactome
Regulation of bone mineralization Source: UniProtKB
Regulation of inflammatory response Source: UniProtKB
Skeletal system development Source: UniProtKB
Cellular Location
Secreted
Involvement in disease
Alopecia-mental retardation syndrome 1 (APMR1): A rare autosomal recessive form of alopecia. APMR1 patients show loss of hair on the scalp, absence of eyebrows, eyelashes, axillary and pubic hair, and mild to severe mental retardation.
PTM
Phosphorylated by FAM20C in the extracellular medium.
O- and N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan at Asn-156: Hex5HexNAc4; N-glycan heterogeneity at Asn-176: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor).
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Anti-AHSG antibodies

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Mouse Anti-AHSG Recombinant Antibody (V2-611056) (CBMAB-A0209-LY)

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Target: AHSG
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: V2-611056
Application*: WB, E
Datasheet SDS

Mouse Anti-AHSG Recombinant Antibody (V2-180308) (CBMAB-A1765-YC)

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Target: AHSG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: V2-180308
Application*: IH, WB, E, IP
Datasheet SDS

Mouse Anti-AHSG Recombinant Antibody (V2-180305) (CBMAB-A1762-YC)

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Target: AHSG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-180305
Application*: E
Datasheet SDS

Mouse Anti-AHSG Recombinant Antibody (V2-180304) (CBMAB-A1761-YC)

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Target: AHSG
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: V2-180304
Application*: E, WB
Datasheet SDS

Rabbit Anti-AHSG Recombinant Antibody (V2-163221) (CBMAB-F3379-CQ)

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Target: AHSG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: V2-163221
Application*: P
Datasheet SDS

Rat Anti-AHSG Recombinant Antibody (V2-162860) (CBMAB-F3005-CQ)

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Target: AHSG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: V2-162860
Application*: WB
Datasheet SDS

Mouse Anti-AHSG Recombinant Antibody (V2-162541) (CBMAB-F2651-CQ)

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Target: AHSG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-162541
Application*: E, WB, IF, IP, IH
Datasheet SDS

Mouse Anti-AHSG Recombinant Antibody (V2-161651) (CBMAB-F1635-CQ)

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Target: AHSG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-161651
Application*: WB
Datasheet SDS

Rabbit Anti-AHSG Recombinant Antibody (V2-160820) (CBMAB-F0748-CQ)

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Target: AHSG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-160820
Application*: E, IF
Datasheet SDS

AHSG Matched Antibody Pair (040) (APMAB-040LY)

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Target: AHSG
Specificity: Human
Datasheet SDS

AHSG Matched Antibody Pair (039) (APMAB-039LY)

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Target: AHSG
Specificity: Human
Datasheet SDS

AHSG Matched Antibody Pair (038) (APMAB-038LY)

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Target: AHSG
Specificity: Human
Datasheet SDS

Mouse Anti-AHSG Recombinant Antibody (V2-161901) (CBMAB-F1918-CQ)

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Target: AHSG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: V2-161901
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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