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Mouse Anti-AHSP Recombinant Antibody (V2-180310) (CBMAB-A1767-YC)

Provided herein is a Mouse monoclonal antibody against Human Alpha Hemoglobin Stabilizing Protein. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all AHSP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-180310
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-102 from human AHSP with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in PBS pH 7.4
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Alpha Hemoglobin Stabilizing Protein
Introduction
AHSP is a molecular chaperone which binds specifically to free alpha-globin and is involved in hemoglobin assembly. The encoded protein binds to monomeric alpha-globin until it has been transferred to beta-globin to form a heterodimer, which in turn binds
Entrez Gene ID
51327
UniProt ID
Q9NZD4
Alternative Names
Alpha Hemoglobin Stabilizing Protein; Erythroid Differentiation-Related Factor; Alpha Hemoglobin Stabilising Protein; ERAF; EDRF; Erythroid Differentiation Associated Factor; Alpha-Hemoglobin-Stabilizing Protein; Erythroid Associated Factor; Erythroid-Ass
Function
Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.
Biological Process
Erythrocyte differentiation Source: GO_Central
Hemoglobin metabolic process Source: UniProtKB
Hemopoiesis Source: UniProtKB
Protein folding Source: GO_Central
Protein stabilization Source: GO_Central
Cellular Location
Cytoplasm

Yaacob, N. S. C., Islam, M. A., Alsaleh, H., Ibrahim, I. K., & Hassan, R. (2020). Alpha-hemoglobin-stabilizing protein (AHSP): a modulatory factor in β-thalassemia. International journal of hematology, 111(3), 352-359.

Walczak, J., Camargo Johnson, M. D., & Muthumalaiappan, K. (2020). Stage Specific Expression Pattern of Alpha-Hemoglobin-Stabilizing-Protein (AHSP) Portrayed in Erythroblast Chronology. Methods and protocols, 3(3), 46.

Muthumalaiappan, K., Walczak, J., Johnson, C., & Bunn, C. (2020). 48 Burn Injury Impedes Late Erythropoiesis via Decreased Alpha Hemoglobin Stabilizing Protein and siglec1. Journal of Burn Care & Research, 41(Supplement_1), S31-S32.

Ray, R., Kalantri, S. A., Bhattacharjee, S., Biswas, A., Shahab, A., Biswas, S., & Bhattacharyya, M. (2019). Association of alpha hemoglobin–stabilizing protein (AHSP) gene mutation and disease severity among HbE—beta thalassemia patients. Annals of hematology, 98(8), 1827-1834.

Lechauve, C., Butcher, J. T., Freiwan, A., Biwer, L. A., Keith, J. M., Good, M. E., ... & Weiss, M. J. (2018). Endothelial cell α-globin and its molecular chaperone α-hemoglobin–stabilizing protein regulate arteriolar contractility. The Journal of clinical investigation, 128(11), 5073-5082.

SAMIA, H. K., AHMEDY, I. A., MAHMOUD, A., & SAFAA, I. T. (2018). Role of alpha hemoglobin stabilizing protein expression in beta thalassemia patients. The Medical Journal of Cairo University, 86(December), 4279-4288.

Straub, A. C., & Gladwin, M. T. (2018). Escorting α-globin to eNOS: α-globin–stabilizing protein paves the way. The Journal of clinical investigation, 128(11), 4755-4757.

Surapolchai, P., Chuansumrit, A., Sirachainan, N., Kadegasem, P., Leung, K. C., & So, C. C. (2017). A molecular study on the role of alpha-hemoglobin-stabilizing protein in hemoglobin H disease. Annals of hematology, 96(6), 1005-1014.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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