Human Recombinant AHSP protein, Biotin Conjugated (V2LY-0526-LY1964)

Name: Human Recombinant AHSP protein, Biotin Conjugated
SKU: V2LY-0526-LY1964
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Protein Construction

This product is Human Recombinant AHSP protein, Biotin Conjugated consist of Amino Acid: 1-102 and predicts a molecular mass of 11.84 kDa.

Molecule Mass

11.84 kDa

Conjugates

Biotin

Sequence

Amino Acid: 1-102

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Alpha Hemoglobin Stabilizing Protein

Function

Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.

Biological Process

Erythrocyte differentiation Source: GO_Central
Hemoglobin metabolic process Source: UniProtKB
Hemopoiesis Source: UniProtKB
Protein folding Source: GO_Central
Protein stabilization Source: GO_Central

Cellular Location

Cytoplasm

Yaacob, N. S. C., Islam, M. A., Alsaleh, H., Ibrahim, I. K., & Hassan, R. (2020). Alpha-hemoglobin-stabilizing protein (AHSP): a modulatory factor in β-thalassemia. International journal of hematology, 111(3), 352-359.

Walczak, J., Camargo Johnson, M. D., & Muthumalaiappan, K. (2020). Stage Specific Expression Pattern of Alpha-Hemoglobin-Stabilizing-Protein (AHSP) Portrayed in Erythroblast Chronology. Methods and protocols, 3(3), 46.

Muthumalaiappan, K., Walczak, J., Johnson, C., & Bunn, C. (2020). 48 Burn Injury Impedes Late Erythropoiesis via Decreased Alpha Hemoglobin Stabilizing Protein and siglec1. Journal of Burn Care & Research, 41(Supplement_1), S31-S32.

Ray, R., Kalantri, S. A., Bhattacharjee, S., Biswas, A., Shahab, A., Biswas, S., & Bhattacharyya, M. (2019). Association of alpha hemoglobin–stabilizing protein (AHSP) gene mutation and disease severity among HbE—beta thalassemia patients. Annals of hematology, 98(8), 1827-1834.

Lechauve, C., Butcher, J. T., Freiwan, A., Biwer, L. A., Keith, J. M., Good, M. E., ... & Weiss, M. J. (2018). Endothelial cell α-globin and its molecular chaperone α-hemoglobin–stabilizing protein regulate arteriolar contractility. The Journal of clinical investigation, 128(11), 5073-5082.

SAMIA, H. K., AHMEDY, I. A., MAHMOUD, A., & SAFAA, I. T. (2018). Role of alpha hemoglobin stabilizing protein expression in beta thalassemia patients. The Medical Journal of Cairo University, 86(December), 4279-4288.

Straub, A. C., & Gladwin, M. T. (2018). Escorting α-globin to eNOS: α-globin–stabilizing protein paves the way. The Journal of clinical investigation, 128(11), 4755-4757.

Surapolchai, P., Chuansumrit, A., Sirachainan, N., Kadegasem, P., Leung, K. C., & So, C. C. (2017). A molecular study on the role of alpha-hemoglobin-stabilizing protein in hemoglobin H disease. Annals of hematology, 96(6), 1005-1014.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant AHSP protein (CAT#: V2LY-0526-LY1963)

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Human Recombinant AHSP protein (CAT#: V2LY-0526-LY1963)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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