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Mouse Anti-AKT1S1 Recombinant Antibody (AKT1S1-3) (CBMAB-0045CQ)

This product is a mouse antibody that recognizes AKT1S1. The antibody AKT1S1-3 can be used for immunoassay techniques such as: IP, WB.
Host Species
Mouse
Application
IP, WB
Immunogen
Fusion protein from Human PRAS40 (N terminal)
Antibody Isotype
IgG1
Specificity
Human
Clone
AKT1S1-3
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Introduction
AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein when phosphorylated. Akt1s1, which they called Pras40, from rat hepatoma cells. By EST database analysis, they identified mouse and human PRAS40. The deduced 256-amino acid human protein contains 2 N-terminal proline-rich regions and a C-terminal AKT phosphorylation site, thr246, that is conserved in rat and mouse. mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. Inhibits RHEB-GTP-dependent mTORC1 activation. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. May also play a role in nerve growth factor-mediated neuroprotection.
Alternative Name
AKT1 Substrate 1 (Proline-Rich); 40 KDa Proline-Rich AKT Substrate; PRAS40; Proline-Rich Akt Substrate; 40 KDa; Lobe
Entrez Gene ID
UniProt ID
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For Research Use Only. Not For Clinical Use.
Cat CBMAB-0045CQ
Conjugates
Size
Price $
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Second antibody and isotype control