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Mouse Anti-ALPL Recombinant Antibody (CBT3985) (V2LY-0625-LY2692)


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Tested Data
Mouse Anti-ALPL Recombinant Antibody (CBT3985) (V2LY-0625-LY2692) in WB
Mouse Anti-ALPL Recombinant Antibody (CBT3985) (V2LY-0625-LY2692) in WB
Mouse Anti-ALPL Recombinant Antibody (CBT3985) (V2LY-0625-LY2692) in WB
Mouse Anti-ALPL Recombinant Antibody (CBT3985) (V2LY-0625-LY2692) in WB
Mouse Anti-ALPL Recombinant Antibody (CBT3985) (V2LY-0625-LY2692) in IHC
Mouse Anti-ALPL Recombinant Antibody (CBT3985) (V2LY-0625-LY2692) in IHC
Mouse Anti-ALPL Recombinant Antibody (CBT3985) (V2LY-0625-LY2692) in FC
Mouse Anti-ALPL Recombinant Antibody (CBT3985) (V2LY-0625-LY2692) in FC
Mouse Anti-ALPL Recombinant Antibody (CBT3985) (V2LY-0625-LY2692) in ELISA
Mouse Anti-ALPL Recombinant Antibody (CBT3985) (V2LY-0625-LY2692) in ELISA

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3985
Antibody Isotype
IgG1
Application
WB, IHC, FC

Basic Information

Immunogen
Purified recombinant fragment of human ALPL expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
249
UniProt ID
P05186
Function
This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi).
Biological Process
Cellular response to organic cyclic compound Source: Ensembl
Cementum mineralization Source: Ensembl
Dephosphorylation Source: GO_Central
Developmental process involved in reproduction Source: Ensembl
Endochondral ossification Source: Ensembl
Osteoblast differentiation Source: UniProtKB
Response to antibiotic Source: Ensembl
Response to glucocorticoid Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to vitamin D Source: BHF-UCL
Skeletal system development Source: ProtInc
Cellular Location
Cell membrane
Involvement in disease
Hypophosphatasia (HOPS): A metabolic bone disease characterized by defective skeletal mineralization and biochemically by deficient activity of the tissue non-specific isoenzyme of alkaline phosphatase. Four forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. The adult form is mild and characterized by recurrent fractures, osteomalacia, rickets, and loss of teeth. Some cases are asymptomatic, while some patients manifest dental features without skeletal manifestations (odontohypophosphatasia).
Hypophosphatasia childhood type (HOPSC): A bone disease characterized by defective skeletal mineralization and biochemically by deficient activity of the tissue non-specific isoenzyme of alkaline phosphatase.
Hypophosphatasia infantile type (HOPSI): A severe bone disease characterized by defective skeletal mineralization and biochemically by deficient activity of the tissue non-specific isoenzyme of alkaline phosphatase. Three more or less distinct types of infantile hypophosphatasia can be identified: (1) type 1 with onset in utero or in early postnatal life, craniostenosis, severe skeletal abnormalities, hypercalcemia, and death in the first year or so of life; (2) type 2 with later, more gradual development of symptoms, moderately severe 'rachitic' skeletal changes and premature loss of teeth; (3) type 3 with no symptoms, the condition being determined on routine studies.
PTM
N-glycosylated.
More Infomation
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For research use only. Not intended for any clinical use.

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