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Mouse Anti-ALPL Recombinant Antibody (W8B2B10) (CBMAB-A2426-YC)

Provided herein is a Mouse monoclonal antibody against Human Alkaline Phosphatase, Liver/Bone/Kidney. The antibody can be used for immunoassay techniques, such as FC, IF, IHC-Fr.
See all ALPL antibodies

Summary

Host Animal
Mouse
Specificity
Dog, Goat, Human, Sheep, Pig
Clone
W8B2B10
Antibody Isotype
IgG1
Application
FC, IF

Basic Information

Immunogen
WERI-RB-1 retinoblastoma cell line
Host Species
Mouse
Specificity
Dog, Goat, Human, Sheep, Pig
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
FC1-4 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
15mM sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Alkaline Phosphatase, Liver/Bone/Kidney
Introduction
ALPL is a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together o
Entrez Gene ID
Human249
Cattle280994
UniProt ID
HumanP05186
CattleP09487
Alternative Names
Alkaline Phosphatase, Liver/Bone/Kidney; Alkaline Phosphatase Liver/Bone/Kidney Isozyme; EC 3.1.3.1; AP-TNAP; TNSALP; Alkaline Phosphatase, Tissue-Nonspecific Isozyme;
Function
This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi).
Biological Process
Cellular response to organic cyclic compound Source: Ensembl
Cementum mineralization Source: Ensembl
Dephosphorylation Source: GO_Central
Developmental process involved in reproduction Source: Ensembl
Endochondral ossification Source: Ensembl
Osteoblast differentiation Source: UniProtKB
Response to antibiotic Source: Ensembl
Response to glucocorticoid Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to vitamin D Source: BHF-UCL
Skeletal system development Source: ProtInc
Cellular Location
Cell membrane
Involvement in disease
Hypophosphatasia (HOPS): A metabolic bone disease characterized by defective skeletal mineralization and biochemically by deficient activity of the tissue non-specific isoenzyme of alkaline phosphatase. Four forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. The adult form is mild and characterized by recurrent fractures, osteomalacia, rickets, and loss of teeth. Some cases are asymptomatic, while some patients manifest dental features without skeletal manifestations (odontohypophosphatasia).
Hypophosphatasia childhood type (HOPSC): A bone disease characterized by defective skeletal mineralization and biochemically by deficient activity of the tissue non-specific isoenzyme of alkaline phosphatase.
Hypophosphatasia infantile type (HOPSI): A severe bone disease characterized by defective skeletal mineralization and biochemically by deficient activity of the tissue non-specific isoenzyme of alkaline phosphatase. Three more or less distinct types of infantile hypophosphatasia can be identified: (1) type 1 with onset in utero or in early postnatal life, craniostenosis, severe skeletal abnormalities, hypercalcemia, and death in the first year or so of life; (2) type 2 with later, more gradual development of symptoms, moderately severe 'rachitic' skeletal changes and premature loss of teeth; (3) type 3 with no symptoms, the condition being determined on routine studies.
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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