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ALPL

This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]
Full Name
Alkaline Phosphatase, Liver/Bone/Kidney
Function
This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi).
Biological Process
Cellular response to organic cyclic compound Source: Ensembl
Cementum mineralization Source: Ensembl
Dephosphorylation Source: GO_Central
Developmental process involved in reproduction Source: Ensembl
Endochondral ossification Source: Ensembl
Osteoblast differentiation Source: UniProtKB
Response to antibiotic Source: Ensembl
Response to glucocorticoid Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to vitamin D Source: BHF-UCL
Skeletal system development Source: ProtInc
Cellular Location
Cell membrane
Involvement in disease
Hypophosphatasia (HOPS): A metabolic bone disease characterized by defective skeletal mineralization and biochemically by deficient activity of the tissue non-specific isoenzyme of alkaline phosphatase. Four forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. The adult form is mild and characterized by recurrent fractures, osteomalacia, rickets, and loss of teeth. Some cases are asymptomatic, while some patients manifest dental features without skeletal manifestations (odontohypophosphatasia).
Hypophosphatasia childhood type (HOPSC): A bone disease characterized by defective skeletal mineralization and biochemically by deficient activity of the tissue non-specific isoenzyme of alkaline phosphatase.
Hypophosphatasia infantile type (HOPSI): A severe bone disease characterized by defective skeletal mineralization and biochemically by deficient activity of the tissue non-specific isoenzyme of alkaline phosphatase. Three more or less distinct types of infantile hypophosphatasia can be identified: (1) type 1 with onset in utero or in early postnatal life, craniostenosis, severe skeletal abnormalities, hypercalcemia, and death in the first year or so of life; (2) type 2 with later, more gradual development of symptoms, moderately severe 'rachitic' skeletal changes and premature loss of teeth; (3) type 3 with no symptoms, the condition being determined on routine studies.
PTM
N-glycosylated.

Anti-ALPL antibodies

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Target: ALPL
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBFYM-0004
Application*: WB, IF, IH, IP
Target: ALPL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Bacteria
Clone: VIAP1
Application*: FC, WB
Target: ALPL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: D1
Application*: WB
Target: ALPL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4H1
Application*: E, RNAi, WB
Target: ALPL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Goat, Human, Sheep, Pig
Clone: W8B2B10
Application*: FC, IF
Target: ALPL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: C4
Application*: WB, IF, IH
Target: ALPL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3A7
Application*: WB, E
Target: ALPL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CAP121
Application*: WB
Target: ALPL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG156
Application*: P
Target: ALPL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: B4-78
Application*: FC, IF, IH, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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