Rabbit Anti-ALPP Recombinant Antibody (RM317) (CBMAB-BR024LY)

Name: Rabbit Anti-ALPP Recombinant Antibody (RM317)
SKU: CBMAB-BR024LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

RM317

Application

IHC, WB

Immunogen

A peptide corresponding to the N-terminus of human PLAP (Placental alkaline phosphatase)

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000-1:2,000
IHC	1:500-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 50% glycerol, 1% BSA

Preservative

0.09% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Alkaline Phosphatase, Placental

Introduction

The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]

Entrez Gene ID

250

UniProt ID

P05187

Alternative Names

Alkaline phosphatase, placental type;3.1.3.1;Alkaline phosphatase Regan isozyme;Placental alkaline phosphatase 1;PLAP-1;ALPP;PLAP;

Biological Process

Dephosphorylation Source: GO_Central

Cellular Location

Cell membrane

Topology

Helical: 513-529 aa

Chen, J., Chen, Z., Liu, M., Qiu, T., Feng, D., Zhao, C., ... & Xu, J. (2020). Placental Alkaline Phosphatase Promotes Zika Virus Replication by Stabilizing Viral Proteins through BIP. Mbio, 11(5), e01716-20.

Vimalraj, S. (2020). Alkaline phosphatase: structure, expression and its function in bone mineralization. Gene, 754, 144855.

Fushimi, A., Takeyama, H., Tachibana, T., & Manome, Y. (2020). Osteogenic cocktail induces calcifications in human breast cancer cell line via placental alkaline phosphatase expression. Scientific reports, 10(1), 1-9.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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