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Mouse Anti-AMBP Recombinant Antibody (1C11F7) (CBMAB-R4261-CN)

This product is a mouse antibody that recognizes AMBP of human. The antibody 1C11F7 can be used for immunoassay techniques such as: ELISA, IHC.
See all AMBP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C11F7
Antibody Isotype
IgG3
Application
ELISA, IHC

Basic Information

Immunogen
Recombinant Human protein AMBP
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG3
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, PH 7.4, 50% Glycerol
Preservative
0.03% sodium azide
Concentration
Batch dependent
Purity
>95%
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target

Full Name
Alpha-1-Microglobulin/Bikunin Precursor
Introduction
This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008]
Entrez Gene ID
259
UniProt ID
P02760
Alternative Names
Alpha-1-Microglobulin/Bikunin Precursor; Complex-Forming Glycoprotein Heterogeneous In Charge; Inter-Alpha-Trypsin Inhibitor Light Chain; Growth-Inhibiting Protein 19; Uronic-Acid-Rich Protein; Protein HC; Trypstatin; Uristatin; Bikunin; ITIL;
Function
Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.1 Publication
Trypstatin is a trypsin inhibitor.
Biological Process
Cell adhesion Source: UniProtKB
Female pregnancy Source: UniProtKB
Heme catabolic process Source: UniProtKB
Negative regulation of immune response Source: UniProtKB
Negative regulation of JNK cascade Source: UniProtKB
Protein catabolic process Source: Ensembl
Protein-chromophore linkage Source: UniProtKB-KW
Receptor-mediated endocytosis Source: Reactome
Viral process Source: UniProtKB-KW
Cellular Location
Secreted
PTM
The precursor is proteolytically processed into separately functioning proteins.
3-hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with Cys-53, Lys-111, Lys-137, and Lys-149 to form heterogeneous polycyclic chromophores including hydroxanthommatin. The reaction by alpha-1-microglobulin is autocatalytic; the human protein forms chromophore even when expressed in insect and bacterial cells. The chromophore can react with accessible cysteines forming non-reducible thioether cross-links with other molecules of alpha-1-microglobulin or with other proteins such as Ig alpha-1 chain C region 'Cys-352'.
Heavy chains are interlinked with bikunin via a chondroitin 4-sulfate bridge to the their C-terminal aspartate.
N- and O-glycosylated. N-glycan heterogeneity at Asn-115: Hex5HexNAc4 (major), Hex6HexNAc5 (minor) and dHex1Hex6HexNAc5 (minor). N-glycan at Asn-250: Hex5HexNAc4. O-linkage of the glycosaminoglycan, chondroitin sulfate, at Ser-215 allows cross-linking between the three polypeptide chains.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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