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Rabbit Anti-AMHR2 Recombinant Antibody (CBYC-A559) (CBMAB-A2536-YC)

Provided herein is a Rabbit monoclonal antibody against Human Anti-Mullerian Hormone Receptor Type 2. The antibody can be used for immunoassay techniques, such as WB.
See all AMHR2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYC-A559
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
A synthetic peptide corresponding to amino acids 50-150 of human AMHR2.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 50% glycerol, 0.05% BSA
Preservative
0.02% sodium azide
Concentration
2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ANTI-MULLERIAN HORMONE RECEPTOR TYPE 2
Introduction
AMHR2 is the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the de
Entrez Gene ID
Human269
Mouse110542
UniProt ID
HumanQ16671
MouseQ8K592
Alternative Names
Anti-Mullerian Hormone Receptor Type 2; Muellerian Inhibiting Substance Type II Receptor; Anti-Muellerian Hormone Type II Receptor; AMH Type II Receptor; MIS Type II Receptor; EC 2.7.11.30; MISRII; MISR2;
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
Biological Process
Activin receptor signaling pathway Source: GO_Central
Anti-Mullerian hormone signaling pathway Source: UniProtKB
BMP signaling pathway Source: Reactome
Cellular response to growth factor stimulus Source: GO_Central
Female gonad development Source: Ensembl
Male gonad development Source: Ensembl
Mullerian duct regression Source: UniProtKB
Protein phosphorylation Source: GO_Central
Sex differentiation Source: UniProtKB
Transforming growth factor beta receptor signaling pathway Source: GO_Central
Cellular Location
Membrane
Involvement in disease
Persistent Muellerian duct syndrome 2 (PMDS2): A form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.
Topology
Extracellular: 18-149 aa
Helical: 150-170 aa
Cytoplasmic: 171-573 aa

Hara, S., Sawamura, R., & Kitano, T. (2021). Cortisol induces masculinization of XX medaka through gonadal soma-derived growth factor (GSDF) and anti-Müllerian hormone receptor type 2 (AMHR2). Fisheries Science, 87(1), 85-91.

Ferdousy, R. N., Kereilwe, O., & Kadokawa, H. (2020). Anti-Müllerian hormone receptor type 2 (AMHR2) expression in bovine oviducts and endometria: comparison of AMHR2 mRNA and protein abundance between old Holstein and young and old Wagyu females. Reproduction, Fertility and Development, 32(8), 738-747.

Sansone, A., Isidori, A. M., Kliesch, S., & Schlatt, S. (2020). Immunohistochemical characterization of the anti-Müllerian hormone receptor type 2 (AMHR-2) in human testes. Endocrine, 68(1), 215-221.

Mazumder, S., Swank, V., Komar, A. A., Johnson, J. M., & Tuohy, V. K. (2020). Immunotherapy of ovarian cancer with a monoclonal antibody specific for the extracellular domain of anti-Müllerian hormone receptor II. Oncotarget, 11(20), 1894.

Kereilwe, O., & Kadokawa, H. (2020). Decreased Anti-Müllerian hormone and Anti-Müllerian hormone receptor type 2 in hypothalami of old Japanese Black cows. Journal of Veterinary Medical Science, 82(8), 1113-1117.

Tosca, L., Giltay, J. C., Bouvattier, C., Klijn, A. J., Bouligand, J., Lambert, A. S., ... & Picard, J. Y. (2020). Persistent Müllerian duct syndrome due to anti-Müllerian hormone receptor 2 microdeletions: a diagnostic challenge. Human Reproduction, 35(4), 999-1003.

Kereilwe, O., Pandey, K., Borromeo, V., & Kadokawa, H. (2018). Anti-Müllerian hormone receptor type 2 is expressed in gonadotrophs of postpubertal heifers to control gonadotrophin secretion. Reproduction, Fertility and Development, 30(9), 1192-1203.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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