Human Recombinant AMHR2 protein, hFc Tag (V2LY-0526-LY2071)

Name: Human Recombinant AMHR2 protein, hFc Tag
SKU: V2LY-0526-LY2071
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant AMHR2 protein, hFc Tag consist of Amino Acid: 17-145 and predicts a molecular mass of 40.42 kDa.

Molecule Mass

40.42 kDa

Verified

HPLC

Sequence

Amino Acid: 17-145

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glycerol, GSH

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

ANTI-MULLERIAN HORMONE RECEPTOR TYPE 2

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

Biological Process

Activin receptor signaling pathway Source: GO_Central
Anti-Mullerian hormone signaling pathway Source: UniProtKB
BMP signaling pathway Source: Reactome
Cellular response to growth factor stimulus Source: GO_Central
Female gonad development Source: Ensembl
Male gonad development Source: Ensembl
Mullerian duct regression Source: UniProtKB
Protein phosphorylation Source: GO_Central
Sex differentiation Source: UniProtKB
Transforming growth factor beta receptor signaling pathway Source: GO_Central

Cellular Location

Membrane

Involvement in disease

Persistent Muellerian duct syndrome 2 (PMDS2): A form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.

Topology

Extracellular: 18-149 aa
Helical: 150-170 aa
Cytoplasmic: 171-573 aa

Hara, S., Sawamura, R., & Kitano, T. (2021). Cortisol induces masculinization of XX medaka through gonadal soma-derived growth factor (GSDF) and anti-Müllerian hormone receptor type 2 (AMHR2). Fisheries Science, 87(1), 85-91.

Ferdousy, R. N., Kereilwe, O., & Kadokawa, H. (2020). Anti-Müllerian hormone receptor type 2 (AMHR2) expression in bovine oviducts and endometria: comparison of AMHR2 mRNA and protein abundance between old Holstein and young and old Wagyu females. Reproduction, Fertility and Development, 32(8), 738-747.

Sansone, A., Isidori, A. M., Kliesch, S., & Schlatt, S. (2020). Immunohistochemical characterization of the anti-Müllerian hormone receptor type 2 (AMHR-2) in human testes. Endocrine, 68(1), 215-221.

Mazumder, S., Swank, V., Komar, A. A., Johnson, J. M., & Tuohy, V. K. (2020). Immunotherapy of ovarian cancer with a monoclonal antibody specific for the extracellular domain of anti-Müllerian hormone receptor II. Oncotarget, 11(20), 1894.

Kereilwe, O., & Kadokawa, H. (2020). Decreased Anti-Müllerian hormone and Anti-Müllerian hormone receptor type 2 in hypothalami of old Japanese Black cows. Journal of Veterinary Medical Science, 82(8), 1113-1117.

Tosca, L., Giltay, J. C., Bouvattier, C., Klijn, A. J., Bouligand, J., Lambert, A. S., ... & Picard, J. Y. (2020). Persistent Müllerian duct syndrome due to anti-Müllerian hormone receptor 2 microdeletions: a diagnostic challenge. Human Reproduction, 35(4), 999-1003.

Kereilwe, O., Pandey, K., Borromeo, V., & Kadokawa, H. (2018). Anti-Müllerian hormone receptor type 2 is expressed in gonadotrophs of postpubertal heifers to control gonadotrophin secretion. Reproduction, Fertility and Development, 30(9), 1192-1203.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant AMHR2 protein, GST Tag (CAT#: V2LY-0526-LY2070)

Human Recombinant AMHR2 protein, His Tag (CAT#: V2LY-0526-LY2072)

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Human Recombinant AMHR2 protein, His Tag (CAT#: V2LY-0526-LY2072)

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Rabbit Anti-AMHR2 Recombinant Antibody (CBYC-A559) (CAT#: CBMAB-A2536-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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