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Mouse Anti-ANGPTL2 Recombinant Antibody (A2701) (CBMAB-A2701-YC)

Provided herein is a Mouse monoclonal antibody against Human Angiopoietin Like 2. The antibody can be used for immunoassay techniques, such as WB.
See all ANGPTL2 antibodies
Published Data
Mouse Anti-ANGPTL2 Recombinant Antibody (A2701) in WB
Western blot analysis of FLAG-tagged ANGPTL2 in the liver (upper panel: lean mice, lower panel: db/db mice). ...View More
Sasaki, Y., Ohta, M., Desai, D., Figueiredo, J. L., Whelan, M. C., Sugano, T., ... & Aikawa, M. (2015). Angiopoietin like protein 2 (ANGPTL2) promotes adipose tissue macrophage and T lymphocyte accumulation and leads to insulin resistance. Plos one, 10(7), e0131176.

Summary

Host Animal
Mouse
Specificity
Human
Clone
A2701
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Angiopoietin-like 2, Ile233-Phe492.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Angiopoietin Like 2
Introduction
Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPT
Entrez Gene ID
23452
UniProt ID
Q9UKU9
Alternative Names
Angiopoietin Like 2; Angiopoietin-Like Protein 2; ARP2; Angiopoietin-Related Protein 2; Angiopoietin-Like 2; HARP;
Function
Induces sprouting in endothelial cells through an autocrine and paracrine action.
Biological Process
Angiogenesis Source: GO_Central
Multicellular organism development Source: ProtInc
Cellular Location
Secreted
PTM
N-glycosylated.

Seyhanli, Z., Seyhanli, A., Aksun, S., & Pamuk, B. O. (2021). Evaluation of serum Angiopoietin-like protein 2 (ANGPTL-2), Angiopoietin-like protein 8 (ANGPTL-8), and high-sensitivity C-reactive protein (hs-CRP) levels in patients with gestational diabetes mellitus and normoglycemic pregnant women. The Journal of Maternal-Fetal & Neonatal Medicine, 1-9.

Fukami, H., Morinaga, J., Okadome, Y., Nishiguchi, Y., Iwata, Y., Kanki, T., ... & Mukoyama, M. (2020). Circulating angiopoietin-like protein 2 levels and arterial stiffness in patients receiving maintenance hemodialysis: A cross-sectional study. Atherosclerosis, 315, 18-23.

Ashokachakkaravarthy, K., Rajappa, M., Parameswaran, S., Satheesh, S., Priyadarshini, G., Mohan Raj, P. S., ... & Priyadarssini, M. (2020). Asymmetric dimethylarginine and angiopoietin-like protein-2 are independent predictors of cardiovascular risk in pre-dialysis non-diabetic chronic kidney disease patients. International urology and nephrology, 52(7), 1321-1328.

Horiguchi, H., Kadomatsu, T., Kurahashi, R., Hara, C., Miyata, K., Baba, M., ... & Oike, Y. (2019). Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity. Genes & development, 33(23-24), 1641-1656.

Ishii, T., Furuya, F., Takahashi, K., Shikata, M., Takamura, T., Kobayashi, H., ... & Kitamura, K. (2019). Angiopoietin-like protein 2 promotes the progression of diabetic kidney disease. The Journal of Clinical Endocrinology & Metabolism, 104(1), 172-180.

Caland, L., Labbé, P., Mamarbachi, M., Villeneuve, L., Ferbeyre, G., Noly, P. E., ... & Thorin, É. (2019). Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice. Aging (Albany NY), 11(11), 3832.

Noly, P. E., Labbé, P., Thorin-Trescases, N., Fortier, A., Nguyen, A., Thorin, E., & Carrier, M. (2019). Reduction of plasma angiopoietin-like 2 after cardiac surgery is related to tissue inflammation and senescence status of patients. The journal of thoracic and cardiovascular surgery, 158(3), 792-802.

Yoshinaga, T., Niou, T., Niihara, T., Kajiya, Y., Hori, E., Tomiyoshi, A., ... & Yoshida, M. (2018). Angiopoietin-like protein 2 is a useful biomarker for pancreatic cancer that is associated with type 2 diabetes mellitus and inflammation. Journal of Cancer, 9(24), 4736.

Desjardins, M. P., Thorin-Trescases, N., Sidibé, A., Fortier, C., De Serres, S. A., Larivière, R., ... & Agharazii, M. (2017). Levels of angiopoietin-like-2 are positively associated with aortic stiffness and mortality after kidney transplantation. American journal of hypertension, 30(4), 409-416.

Takano, A., Fukuda, T., Shinjo, T., Iwashita, M., Matsuzaki, E., Yamamichi, K., ... & Nishimura, F. (2017). Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation. Metabolism, 69, 157-170.

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For research use only. Not intended for any clinical use.

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