Mouse Recombinant ANGPTL2 protein, hFc Tag (V2LY-0526-LY7808)

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Basic Information

Expressed Host
HEK293 Cells
Protein Species
Mouse
Tag
hFc Tag
Protein Construction
This product is Mouse Recombinant ANGPTL2 protein, hFc Tag consist of Amino Acid: 245-493 and predicts a molecular mass of 57.5 kDa.
Molecule Mass
57.5 kDa
Sequence
Amino Acid: 245-493
Species
Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Format
Lyophilized
Reconstitution
Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.
Buffer
Lyophilized from sterile PBS
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
Angiopoietin Like 2
Function
Induces sprouting in endothelial cells through an autocrine and paracrine action.
Biological Process
Angiogenesis Source: GO_Central
Multicellular organism development Source: ProtInc
Cellular Location
Secreted
PTM
N-glycosylated.

Seyhanli, Z., Seyhanli, A., Aksun, S., & Pamuk, B. O. (2021). Evaluation of serum Angiopoietin-like protein 2 (ANGPTL-2), Angiopoietin-like protein 8 (ANGPTL-8), and high-sensitivity C-reactive protein (hs-CRP) levels in patients with gestational diabetes mellitus and normoglycemic pregnant women. The Journal of Maternal-Fetal & Neonatal Medicine, 1-9.

Fukami, H., Morinaga, J., Okadome, Y., Nishiguchi, Y., Iwata, Y., Kanki, T., ... & Mukoyama, M. (2020). Circulating angiopoietin-like protein 2 levels and arterial stiffness in patients receiving maintenance hemodialysis: A cross-sectional study. Atherosclerosis, 315, 18-23.

Ashokachakkaravarthy, K., Rajappa, M., Parameswaran, S., Satheesh, S., Priyadarshini, G., Mohan Raj, P. S., ... & Priyadarssini, M. (2020). Asymmetric dimethylarginine and angiopoietin-like protein-2 are independent predictors of cardiovascular risk in pre-dialysis non-diabetic chronic kidney disease patients. International urology and nephrology, 52(7), 1321-1328.

Horiguchi, H., Kadomatsu, T., Kurahashi, R., Hara, C., Miyata, K., Baba, M., ... & Oike, Y. (2019). Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity. Genes & development, 33(23-24), 1641-1656.

Ishii, T., Furuya, F., Takahashi, K., Shikata, M., Takamura, T., Kobayashi, H., ... & Kitamura, K. (2019). Angiopoietin-like protein 2 promotes the progression of diabetic kidney disease. The Journal of Clinical Endocrinology & Metabolism, 104(1), 172-180.

Caland, L., Labbé, P., Mamarbachi, M., Villeneuve, L., Ferbeyre, G., Noly, P. E., ... & Thorin, É. (2019). Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice. Aging (Albany NY), 11(11), 3832.

Noly, P. E., Labbé, P., Thorin-Trescases, N., Fortier, A., Nguyen, A., Thorin, E., & Carrier, M. (2019). Reduction of plasma angiopoietin-like 2 after cardiac surgery is related to tissue inflammation and senescence status of patients. The journal of thoracic and cardiovascular surgery, 158(3), 792-802.

Yoshinaga, T., Niou, T., Niihara, T., Kajiya, Y., Hori, E., Tomiyoshi, A., ... & Yoshida, M. (2018). Angiopoietin-like protein 2 is a useful biomarker for pancreatic cancer that is associated with type 2 diabetes mellitus and inflammation. Journal of Cancer, 9(24), 4736.

Desjardins, M. P., Thorin-Trescases, N., Sidibé, A., Fortier, C., De Serres, S. A., Larivière, R., ... & Agharazii, M. (2017). Levels of angiopoietin-like-2 are positively associated with aortic stiffness and mortality after kidney transplantation. American journal of hypertension, 30(4), 409-416.

Takano, A., Fukuda, T., Shinjo, T., Iwashita, M., Matsuzaki, E., Yamamichi, K., ... & Nishimura, F. (2017). Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation. Metabolism, 69, 157-170.

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For research use only. Not intended for any clinical use.

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