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Mouse Anti-ANGPTL2 Recombinant Antibody (CBFYH-0014) (CBMAB-H0821-FY)

This product is mouse antibody that recognizes ANGPTL2. The antibody CBFYH-0014 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-Fr, ELISA.
See all ANGPTL2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYH-0014
Antibody Isotype
IgG1, κ
Application
WB, IHC, ICC, IF

Basic Information

Immunogen
Amino acids 158-254 mapping within an internal region of Angptl2 of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:30-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Angiopoietin Like 2
Introduction
Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action.
Entrez Gene ID
23452
UniProt ID
Q9UKU9
Alternative Names
Angiopoietin Like 2; Angiopoietin-Like Protein 2; ARP2; Angiopoietin-Related Protein 2; Angiopoietin-Like 2; HARP
Function
Induces sprouting in endothelial cells through an autocrine and paracrine action.
Biological Process
Angiogenesis Source: GO_Central
Multicellular organism development Source: ProtInc
Cellular Location
Secreted
PTM
N-glycosylated.

Seyhanli, Z., Seyhanli, A., Aksun, S., & Pamuk, B. O. (2021). Evaluation of serum Angiopoietin-like protein 2 (ANGPTL-2), Angiopoietin-like protein 8 (ANGPTL-8), and high-sensitivity C-reactive protein (hs-CRP) levels in patients with gestational diabetes mellitus and normoglycemic pregnant women. The Journal of Maternal-Fetal & Neonatal Medicine, 1-9.

Fukami, H., Morinaga, J., Okadome, Y., Nishiguchi, Y., Iwata, Y., Kanki, T., ... & Mukoyama, M. (2020). Circulating angiopoietin-like protein 2 levels and arterial stiffness in patients receiving maintenance hemodialysis: A cross-sectional study. Atherosclerosis, 315, 18-23.

Ashokachakkaravarthy, K., Rajappa, M., Parameswaran, S., Satheesh, S., Priyadarshini, G., Mohan Raj, P. S., ... & Priyadarssini, M. (2020). Asymmetric dimethylarginine and angiopoietin-like protein-2 are independent predictors of cardiovascular risk in pre-dialysis non-diabetic chronic kidney disease patients. International urology and nephrology, 52(7), 1321-1328.

Horiguchi, H., Kadomatsu, T., Kurahashi, R., Hara, C., Miyata, K., Baba, M., ... & Oike, Y. (2019). Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity. Genes & development, 33(23-24), 1641-1656.

Ishii, T., Furuya, F., Takahashi, K., Shikata, M., Takamura, T., Kobayashi, H., ... & Kitamura, K. (2019). Angiopoietin-like protein 2 promotes the progression of diabetic kidney disease. The Journal of Clinical Endocrinology & Metabolism, 104(1), 172-180.

Caland, L., Labbé, P., Mamarbachi, M., Villeneuve, L., Ferbeyre, G., Noly, P. E., ... & Thorin, É. (2019). Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice. Aging (Albany NY), 11(11), 3832.

Noly, P. E., Labbé, P., Thorin-Trescases, N., Fortier, A., Nguyen, A., Thorin, E., & Carrier, M. (2019). Reduction of plasma angiopoietin-like 2 after cardiac surgery is related to tissue inflammation and senescence status of patients. The journal of thoracic and cardiovascular surgery, 158(3), 792-802.

Yoshinaga, T., Niou, T., Niihara, T., Kajiya, Y., Hori, E., Tomiyoshi, A., ... & Yoshida, M. (2018). Angiopoietin-like protein 2 is a useful biomarker for pancreatic cancer that is associated with type 2 diabetes mellitus and inflammation. Journal of Cancer, 9(24), 4736.

Desjardins, M. P., Thorin-Trescases, N., Sidibé, A., Fortier, C., De Serres, S. A., Larivière, R., ... & Agharazii, M. (2017). Levels of angiopoietin-like-2 are positively associated with aortic stiffness and mortality after kidney transplantation. American journal of hypertension, 30(4), 409-416.

Takano, A., Fukuda, T., Shinjo, T., Iwashita, M., Matsuzaki, E., Yamamichi, K., ... & Nishimura, F. (2017). Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation. Metabolism, 69, 157-170.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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